UniProtKB/Swiss-Prot protein knowledgebase release 2026_03 statistics
1. INTRODUCTION
Release 2026_03 of 02-Sep-2026 of UniProtKB/Swiss-Prot contains 575748 sequence
entries, curated from 313807 unique references and comprising 209017843 amino acids.
247 sequences have been added since release 2026_02, the sequence data of
29 existing entries has been updated and the annotations of
403255 entries have been revised.
Number of fragments: 9308
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 41355
Protein existence (PE): entries %
1: Evidence at protein level 121477 21.1%
2: Evidence at transcript level 54431 9.5%
3: Inferred from homology 385442 66.9%
4: Predicted 12668 2.2%
5: Uncertain 1730 0.3%
The growth of the database is summarized below.
2. TAXONOMIC ORIGIN
Total number of species represented in this release of UniProtKB/Swiss-Prot: 14919
The first twenty species represent 123494 sequences: 21.4 % of the total
number of entries.
2.1 Table of the frequency of occurrence of species
Species represented 1x: 6065
2x: 2164
3x: 1174
4x: 795
5x: 553
6x: 447
7x: 338
8x: 289
9x: 243
10x: 161
11- 20x: 865
21- 50x: 525
51-100x: 237
>100x: 1063
2.2 Table of the most represented species
------ --------- --------------------------------------------
Number Frequency Species
------ --------- --------------------------------------------
1 20431 Homo sapiens (Human)
2 17283 Mus musculus (Mouse)
3 16421 Arabidopsis thaliana (Mouse-ear cress)
4 8233 Rattus norvegicus (Rat)
5 6733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
6 6054 Bos taurus (Bovine)
7 5129 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
8 4531 Escherichia coli (strain K12)
9 4489 Caenorhabditis elegans
10 4197 Oryza sativa subsp. japonica (Rice)
11 4191 Bacillus subtilis (strain 168)
12 4163 Dictyostelium discoideum (Social amoeba)
13 3904 Drosophila melanogaster (Fruit fly)
14 3523 Xenopus laevis (African clawed frog)
15 3385 Danio rerio (Zebrafish) (Brachydanio rerio)
16 2344 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
17 2318 Gallus gallus (Chicken)
18 2218 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
19 2048 Escherichia coli O157:H7
20 1899 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
21 1833 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
22 1786 Methanocaldococcus jannaschii
23 1714 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
24 1703 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
25 1702 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
26 1696 Shigella flexneri
27 1506 Pseudomonas aeruginosa
28 1463 Sus scrofa (Pig)
29 1349 Salmonella typhi
30 1244 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
31 1198 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
32 1176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
33 1111 Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
34 1038 Archaeoglobus fulgidus
35 1031 Yersinia pestis
36 1030 Emericella nidulans
37 1000 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
38 981 Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
39 980 Neurospora crassa
40 979 Oryctolagus cuniculus (Rabbit)
41 945 Staphylococcus aureus (strain Mu50 / ATCC 700699)
42 930 Salmonella paratyphi A (strain ATCC 9150 / SARB42)
43 930 Staphylococcus aureus (strain N315)
44 929 Eremothecium gossypii
45 920 Kluyveromyces lactis
46 909 Acanthamoeba polyphaga mimivirus (APMV)
47 905 Staphylococcus aureus (strain COL)
48 896 Staphylococcus aureus (strain MW2)
49 894 Escherichia coli O6:K15:H31 (strain 536 / UPEC)
50 892 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
51 891 Candida glabrata
52 890 Staphylococcus aureus (strain MSSA476)
53 888 Staphylococcus aureus (strain MRSA252)
54 882 Salmonella choleraesuis (strain SC-B67)
55 879 Shigella sonnei (strain Ss046)
56 877 Oryza sativa subsp. indica (Rice)
57 863 Yersinia pseudotuberculosis serotype I (strain IP32953)
58 857 Canis lupus familiaris (Dog) (Canis familiaris)
59 850 Zea mays (Maize)
60 847 Escherichia coli O9:H4 (strain HS)
61 838 Escherichia coli O139:H28 (strain E24377A / ETEC)
62 829 Shigella boydii serotype 4 (strain Sb227)
63 825 Escherichia coli (strain UTI89 / UPEC)
64 822 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
65 822 Shigella dysenteriae serotype 1 (strain Sd197)
66 822 Escherichia coli
67 817 Staphylococcus aureus (strain NCTC 8325 / PS 47)
68 804 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
69 798 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
70 791 Escherichia coli (strain SMS-3-5 / SECEC)
71 788 Aquifex aeolicus (strain VF5)
72 779 Escherichia coli O127:H6 (strain E2348/69 / EPEC)
73 771 Escherichia coli (strain K12 / DH10B)
74 770 Pasteurella multocida (strain Pm70)
75 767 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
76 765 Escherichia coli (strain K12 / MC4100 / BW2952)
77 762 Escherichia coli (strain 55989 / EAEC)
78 761 Escherichia coli O8 (strain IAI1)
79 760 Shigella flexneri serotype 5b (strain 8401)
80 760 Staphylococcus epidermidis
81 760 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
82 759 Escherichia coli O45:K1 (strain S88 / ExPEC)
83 758 Bacillus anthracis
84 756 Escherichia coli (strain SE11)
85 753 Escherichia coli O7:K1 (strain IAI39 / ExPEC)
86 749 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
87 748 Escherichia coli O157:H7 (strain EC4115 / EHEC)
88 745 Pseudomonas putida
89 744 Halalkalibacterium halodurans
90 744 Escherichia coli
91 739 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
92 733 Vibrio vulnificus (strain CMCP6)
93 731 Escherichia coli O81 (strain ED1a)
94 722 Salmonella enteritidis PT4 (strain P125109)
95 721 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
96 718 Vibrio vulnificus (strain YJ016)
97 716 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
98 715 Enterobacter sp. (strain 638)
99 715 Escherichia coli O1:K1 / APEC
100 715 Yersinia pestis bv. Antiqua (strain Nepal516)
101 714 Salmonella paratyphi A (strain AKU_12601)
102 713 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
103 713 Salmonella agona (strain SL483)
104 713 Salmonella newport (strain SL254)
105 712 Salmonella schwarzengrund (strain CVM19633)
106 711 Yersinia pestis bv. Antiqua (strain Antiqua)
107 710 Salmonella heidelberg (strain SL476)
108 708 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
109 702 Salmonella dublin (strain CT_02021853)
110 699 Klebsiella variicola (strain 342) (Klebsiella pneumoniae)
111 698 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
112 695 Escherichia fergusonii
113 692 Pan troglodytes (Chimpanzee)
114 686 Mycoplasmoides pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
115 684 Staphylococcus aureus (strain USA300)
116 684 Salmonella gallinarum (strain 287/91 / NCTC 13346)
117 683 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
118 680 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
119 679 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
120 672 Serratia proteamaculans (strain 568)
121 672 Bacillus cereus
122 669 Mycobacterium leprae (strain TN)
123 668 Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
124 667 Yersinia pestis (strain Pestoides F)
125 667 Bradyrhizobium diazoefficiens
126 663 Shewanella oneidensis
127 658 Sinorhizobium fredii (strain NBRC 101917 / NGR234)
128 653 Debaryomyces hansenii
129 643 Staphylococcus aureus (strain bovine RF122 / ET3-1)
130 642 Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
131 642 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
132 634 Yersinia pseudotuberculosis serotype IB (strain PB1/+)
133 623 Methanothermobacter thermautotrophicus
134 623 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
135 622 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
136 622 Treponema pallidum (strain DSM 117211 / Nichols)
137 621 Pseudomonas aeruginosa (strain UCBPP-PA14)
138 616 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
139 615 Xanthomonas campestris pv. campestris
140 614 Staphylococcus haemolyticus (strain JCSC1435)
141 614 Mesorhizobium japonicum (Mesorhizobium loti
142 614 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
143 605 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
144 604 Ralstonia nicotianae (strain ATCC BAA-1114 / GMI1000) (Ralstonia solanacearum)
145 602 Photobacterium profundum (strain SS9)
146 602 Staphylococcus saprophyticus subsp. saprophyticus
147 601 Salmonella paratyphi C (strain RKS4594)
148 600 Yersinia pestis bv. Antiqua (strain Angola)
149 595 Bacillus cereus (strain ATCC 10987 / NRS 248)
150 592 Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
151 592 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
152 591 Pectobacterium carotovorum subsp. carotovorum (strain PC1)
153 584 Rickettsia prowazekii (strain Madrid E)
154 582 Caenorhabditis briggsae
155 579 Brucella suis biovar 1 (strain 1330)
156 577 Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15)
157 576 Brucella melitensis biotype 1
158 573 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
159 572 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
160 569 Bacillus thuringiensis subsp. konkukian (strain 97-27)
161 568 Pseudomonas syringae pv. syringae (strain B728a)
162 568 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
163 567 Thermotoga maritima
164 567 Bacillus licheniformis
165 562 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
166 562 Bacillus cereus (strain ZK / E33L)
167 561 Xanthomonas citri pv. citri (strain 306)
168 559 Clostridium acetobutylicum
169 555 Pseudomonas fluorescens (strain Pf0-1)
170 554 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
171 554 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
172 553 Oceanobacillus iheyensis
173 547 Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola
174 543 Corynebacterium glutamicum
175 541 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
176 533 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
177 531 Staphylococcus aureus (strain Newman)
178 531 Erwinia tasmaniensis
179 530 Listeria monocytogenes serotype 4b (strain F2365)
180 529 Sodalis glossinidius (strain morsitans)
181 525 Deinococcus radiodurans
182 523 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
183 522 Xylella fastidiosa (strain 9a5c)
184 520 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
185 519 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
186 519 Chromobacterium violaceum
187 518 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
188 518 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
189 515 Xylella fastidiosa (strain Temecula1 / ATCC 700964)
190 512 Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
191 512 Pseudomonas paraeruginosa (strain DSM 24068 / PA7) (Pseudomonas aeruginosa
192 512 Haemophilus ducreyi (strain 35000HP / ATCC 700724)
193 512 Geobacillus kaustophilus (strain HTA426)
194 512 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
195 511 Streptomyces avermitilis
196 509 Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
197 508 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
198 507 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
199 507 Nicotiana tabacum (Common tobacco)
200 505 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
201 504 Pseudomonas entomophila (strain DSM 28517 / CCUG 61470 / CECT 7985 / L48)
202 503 Haemophilus influenzae (strain 86-028NP)
203 501 Methanosarcina mazei
204 501 Burkholderia pseudomallei (strain K96243)
205 500 Pyrococcus horikoshii
206 499 Brucella abortus biovar 1 (strain 9-941)
207 498 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
208 497 Xanthomonas campestris pv. campestris (strain 8004)
209 497 Proteus mirabilis (strain HI4320)
210 497 Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)
211 496 Rickettsia conorii (strain ATCC VR-613 / Malish 7)
212 496 Shouchella clausii (strain KSM-K16) (Alkalihalobacillus clausii)
213 495 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
214 493 Brucella abortus (strain 2308)
215 492 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
216 491 Vibrio campbellii (strain ATCC BAA-1116)
217 488 Shewanella sp. (strain MR-7)
218 486 Cupriavidus necator
219 486 Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E)
220 485 Pseudomonas aeruginosa (strain LESB58)
221 485 Shewanella sp. (strain MR-4)
222 484 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
223 484 Staphylococcus aureus (strain Mu3 / ATCC 700698)
224 483 Mycoplasmoides genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
225 480 Pseudomonas putida
226 478 Pyrococcus abyssi (strain GE5 / Orsay)
227 478 Enterococcus faecalis (strain ATCC 700802 / V583)
228 476 Campylobacter jejuni subsp. jejuni serotype O:2
229 475 Burkholderia lata
230 472 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
231 471 Cereibacter sphaeroides
232 470 Clostridium perfringens (strain 13 / Type A)
233 468 Shewanella sp. (strain ANA-3)
234 468 Shewanella frigidimarina (strain NCIMB 400)
235 468 Pseudomonas putida (strain GB-1)
236 467 Aeromonas hydrophila subsp. hydrophila
237 466 Xanthomonas euvesicatoria pv. vesicatoria (strain 85-10)
238 466 Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
239 463 Burkholderia mallei (strain ATCC 23344)
240 462 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
241 461 Ovis aries (Sheep)
242 460 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
243 457 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
244 455 Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
245 455 Staphylococcus aureus (strain JH1)
246 455 Shewanella baltica (strain OS185)
247 453 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
248 453 Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
249 453 Pseudomonas putida (strain W619)
250 452 Aeromonas salmonicida (strain A449)
2.3 Taxonomic distribution of the sequences
Kingdom sequences (% of the database)
Archaea 19908 ( 3%)
Bacteria 337294 ( 59%)
Eukaryota 201017 ( 35%)
Viruses 17529 ( 3%)
Within Eukaryota:
Category sequences (% of Eukaryota) (% of the complete database)
Human 20432 ( 10%) ( 4%)
Other Mammalia 47576 ( 24%) ( 8%)
Other Vertebrata 19102 ( 10%) ( 3%)
Viridiplantae 42106 ( 21%) ( 7%)
Fungi 38451 ( 19%) ( 7%)
Insecta 10168 ( 5%) ( 2%)
Nematoda 5408 ( 3%) ( 1%)
Other 17774 ( 9%) ( 3%)
3. SEQUENCE SIZE
Repartition of the sequences by size (excluding fragments)
From To Number From To Number
1- 50 10081 1001-1100 4202
51- 100 43898 1101-1200 2948
101- 150 60186 1201-1300 2243
151- 200 59888 1301-1400 2100
201- 250 58795 1401-1500 1714
251- 300 52843 1501-1600 854
301- 350 53324 1601-1700 653
351- 400 46408 1701-1800 610
401- 450 38024 1801-1900 546
451- 500 30909 1901-2000 407
501- 550 22669 2001-2100 285
551- 600 16030 2101-2200 401
601- 650 13299 2201-2300 350
651- 700 9510 2301-2400 244
701- 750 7961 2401-2500 206
751- 800 5775 >2500 1541
801- 850 4966
851- 900 5360
901- 950 4169
951-1000 3041
The average sequence length in UniProtKB/Swiss-Prot is 363 amino acids.
The shortest sequence is GWA_SEPOF (P83570): 2 amino acids.
The longest sequence is TITIN_MOUSE (A2ASS6): 35213 amino acids.
4. JOURNAL CITATIONS
Note: the following citation statistics reflect the number of distinct
journal citations.
Total number of journals cited in this release of UniProtKB/Swiss-Prot: 3282
4.1 Table of the frequency of journal citations
Journals cited 1x: 1014
2x: 439
3x: 238
4x: 152
5x: 137
6x: 97
7x: 72
8x: 63
9x: 69
10x: 36
11- 20x: 259
21- 50x: 282
51-100x: 147
>100x: 277
4.2 List of the most cited journals in UniProtKB/Swiss-Prot
Nb Citations Journal name
-- --------- -------------------------------------------------------------
1 28211 Journal of Biological Chemistry
2 13329 Proceedings of the National Academy of Sciences of the U.S.A.
3 7455 Journal of Bacteriology
4 6238 Biochemical and Biophysical Research Communications
5 6084 Biochemistry
6 5546 Nucleic Acids Research
7 5503 Nature
8 5195 FEBS Letters
9 5139 The EMBO Journal
10 4922 Gene
11 4755 Journal of Molecular Biology
12 4683 Molecular and Cellular Biology
13 4155 Biochimica et Biophysica Acta
14 4029 Cell
15 3726 Journal of Virology
16 3583 Science
17 3548 European Journal of Biochemistry
18 3285 Biochemical Journal
19 3028 Molecular Microbiology
20 2893 PLoS ONE
21 2848 Plant Physiology
22 2550 Genomics
23 2511 The American Journal of Human Genetics
24 2450 Journal of Cell Biology
25 2225 The Plant Cell
26 2096 Human Molecular Genetics
27 2054 The Plant Journal
28 2002 Molecular Cell
29 2001 Genes and Development
30 1949 Virology
31 1932 Plant Molecular Biology
32 1886 Nature Genetics
33 1884 Molecular Biology of the Cell
34 1884 Development
35 1871 Nature Communications
36 1782 Journal of Immunology
37 1698 Human Mutation
38 1582 Oncogene
39 1531 Structure
40 1460 Genetics
41 1456 Journal of Biochemistry
42 1447 Journal of Cell Science
43 1445 Molecular and General Genetics
44 1336 Blood
45 1311 Infection and Immunity
46 1229 Microbiology
47 1216 Developmental Biology
48 1203 Journal of General Virology
49 1188 Archives of Biochemistry and Biophysics
50 1185 Current Biology
51 1147 Scientific Reports
52 1093 Journal of Neuroscience
53 1093 Applied and Environmental Microbiology
54 1023 Acta Crystallographica, Section D
55 991 PLoS Genetics
56 980 FEMS Microbiology Letters
57 944 Cancer Research
58 923 American Journal of Physiology
59 921 Toxicon
60 916 Protein Science
61 906 Journal of Clinical Investigation
62 868 Neuron
63 861 Yeast
64 812 The Journal of Experimental Medicine
65 801 PLoS Pathogens
66 792 Nature Structural and Molecular Biology
67 781 Human Genetics
68 778 Plant and Cell Physiology
69 752 Journal of Medical Genetics
70 748 The FEBS Journal
71 727 Proteins
72 693 Nature Cell Biology
73 687 Mechanisms of Development
74 664 Bioscience, Biotechnology, and Biochemistry
75 663 Antimicrobial Agents and Chemotherapy
76 656 Nature Structural Biology
77 643 Cell Reports
78 630 Developmental Cell
79 621 Current Genetics
80 593 Journal of Neurochemistry
81 588
82 587 Journal of the American Chemical Society
83 567 Molecular Endocrinology
84 562 The Journal of Clinical Endocrinology and Metabolism
85 558 Endocrinology
86 553 Molecular and Biochemical Parasitology
87 521 Eukaryotic Cell
88 516 EMBO Reports
89 509 Experimental Cell Research
90 503 RNA
91 502 American Journal of Medical Genetics. Part A
92 496 Mammalian Genome
93 493 The FASEB Journal
94 487 Peptides
95 479 Journal of Experimental Botany
96 464 Planta
97 458 Molecular Pharmacology
98 453 Acta Crystallographica, Section F
99 451 European Journal of Human Genetics
100 448 Clinical Genetics
101 439 Molecular Plant-Microbe Interactions
102 435 Immunogenetics
103 431 Immunity
104 428 Journal of Investigative Dermatology
105 426 Molecular Biology and Evolution
106 409 Journal of Molecular Evolution
107 406 Biochimie
108 406 Neurology
109 400 DNA and Cell Biology
110 391 Biology of Reproduction
111 384 PLoS Biology
112 383 Comparative Biochemistry and Physiology
113 381 DNA Sequence
114 380 Applied Microbiology and Biotechnology
115 374 Genes to Cells
116 372 Nature Immunology
117 367 Virus Research
118 366 Journal of Medicinal Chemistry
119 365 BMC Genomics
120 364 Journal of Lipid Research
121 350 Developmental Dynamics
122 346 The New England Journal of Medicine
123 345 Annals of Neurology
124 343 Brain Research. Molecular Brain Research
125 332 European Journal of Immunology
126 331 Nature Chemical Biology
127 323 Journal of Human Genetics
128 323 Genome Research
129 319 Investigative Ophthalmology and Visual Science
130 310 Brain
131 301 Fungal Genetics and Biology
132 300 Glycobiology
133 299 Biological Chemistry Hoppe-Seyler
134 286 Archives of Microbiology
135 285 Journal of General Microbiology
136 280 Cytogenetics and Cell Genetics
137 280 Cell Research
138 275 Traffic
139 272 Protein Expression and Purification
140 272 Molecular Genetics and Metabolism
141 271 Nature Medicine
142 267 Molecular Immunology
143 264 Phytochemistry
144 258 Journal of Cellular Biochemistry
145 255 Cell Cycle
146 252 Frontiers in Microbiology
147 250 Circulation Research
148 246 ChemBioChem
149 243 New Phytologist
150 243 Insect Biochemistry and Molecular Biology
5. STATISTICS FOR SOME LINE TYPES
The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.
Total Number of Average
Line type / subtype number entries per entry
------------------------------------ -------- --------- ---------
References (RL) 1363375 2.37
Journal 1176770 482729 2.04 1
Submitted to EMBL/GenBank/DDBJ 174859 151223 0.30 2
Submitted to other databases 8009 7277 0.01 3
Book citation 1881 1858 <0.01 4
Plant Gene Register 613 600 <0.01 5
Unpublished observations 544 540 <0.01 6
Thesis 477 474 <0.01 7
Patent 216 209 <0.01 8
Worm Breeder's Gazette 6 6 <0.01 9
Total number of distinct authors cited in UniProtKB/Swiss-Prot: 495550
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Comments (CC) 2826906 4.91
ACTIVITY REGULATION 19959 19820 0.03 17
ALLERGEN 980 980 <0.01 26
ALTERNATIVE PRODUCTS 26039 26039 0.05 14
BIOPHYSICOCHEMICAL PROPERTIES 12675 12612 0.02 20
BIOTECHNOLOGY 2460 2394 <0.01 24
CATALYTIC ACTIVITY 363560 260567 0.63 4
CAUTION 14833 14515 0.03 19
COFACTOR 138103 125568 0.24 7
DEVELOPMENTAL STAGE 14986 14850 0.03 18
DISEASE 8772 5881 0.02 21
DISRUPTION PHENOTYPE 24197 24124 0.04 16
DOMAIN 64670 54211 0.11 9
FUNCTION 504390 476067 0.88 2
INDUCTION 27485 27359 0.05 13
INTERACTION 25413 25413 0.04 15
MASS SPECTROMETRY 7741 5992 0.01 22
MISCELLANEOUS 46791 41120 0.08 11
PATHWAY 145506 131426 0.25 6
PHARMACEUTICAL 169 162 <0.01 29
POLYMORPHISM 1519 1396 <0.01 25
PTM 68313 47958 0.12 8
RNA EDITING 646 646 <0.01 28
SEQUENCE CAUTION 45549 45479 0.08 12
SIMILARITY 523915 519543 0.91 1
SUBCELLULAR LOCATION 371375 362259 0.65 3
SUBUNIT 307977 301887 0.53 5
TISSUE SPECIFICITY 52583 51805 0.09 10
TOXIC DOSE 908 720 <0.01 27
WEB RESOURCE 5392 4861 0.01 23
Total number of comment topics: 29
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Features (FT) 5855152 10.17
ACT_SITE 181409 107745 0.32 10
BINDING 1329061 226732 2.31 1
CARBOHYD 127182 32366 0.22 14
CHAIN 584271 567887 1.01 2
COILED 22912 15855 0.04 25
COMPBIAS 270089 93713 0.47 7
CONFLICT 140453 48898 0.24 13
CROSSLNK 26053 9338 0.05 24
DISULFID 142482 37707 0.25 12
DNA_BIND 12394 11109 0.02 31
DOMAIN 221683 135407 0.39 9
HELIX 465243 35250 0.81 3
INIT_MET 17741 17687 0.03 26
INTRAMEM 3251 1554 0.01 34
LIPID 14264 9089 0.02 28
MOD_RES 269718 75453 0.47 8
MOTIF 49854 32050 0.09 21
MUTAGEN 110984 22079 0.19 15
NON_CONS 2657 833 <0.01 35
NON_STD 361 286 <0.01 36
NON_TER 12615 9708 0.02 30
PEPTIDE 12983 8973 0.02 29
PROPEP 15706 13416 0.03 27
REGION 333483 153152 0.58 6
REPEAT 110741 15359 0.19 16
SIGNAL 45491 45490 0.08 22
SITE 69624 37319 0.12 19
STRAND 414292 32733 0.72 4
TOPO_DOM 155739 31194 0.27 11
TRANSIT 9713 9590 0.02 32
TRANSMEM 386381 80943 0.67 5
TURN 98600 28421 0.17 18
UNSURE 5780 915 0.01 33
VAR_SEQ 53518 22788 0.09 20
VARIANT 107352 17687 0.19 17
ZN_FING 31072 13286 0.05 23
Total number of feature keys: 36
Total Number of Average
Line type / subtype number entries per entry Rank Category
------------------------------------ -------- --------- --------- ---- -------------------------------------------
Cross-references (DR) 21663184 37.63
AbasyAtlas 11759 11759 0.02 98 Gene expression databases
ABCD 3398 3398 0.01 123 Protocols and materials databases
Agora 18462 18413 0.03 86 Miscellaneous databases
AGR 69437 68775 0.12 43 Organism-specific databases
Allergome 2050 1319 <0.01 137 Protein family/group databases
AlphaFoldDB 558355 558355 0.97 10 3D structure databases
Antibodypedia 32381 32272 0.06 61 Protocols and materials databases
AntiFam 22 22 <0.01 173 Family and domain databases
ArachnoServer 1148 1138 <0.01 146 Organism-specific databases
Araport 16441 16345 0.03 92 Organism-specific databases
Bgee 62133 62131 0.11 45 Gene expression databases
BindingDB 8679 8679 0.02 104 Chemistry databases
BioCyc 48350 44294 0.08 54 Enzyme and pathway databases
BioGRID 62686 60648 0.11 44 Protein-protein interaction databases
BioGRID-ORCS 45209 44621 0.08 55 Miscellaneous databases
BioMuta 20285 20258 0.04 75 Genetic variation databases
BMRB 6915 6915 0.01 111 3D structure databases
BRENDA 23378 21097 0.04 69 Enzyme and pathway databases
CarbonylDB 1159 1159 <0.01 145 PTM databases
CARD 327 325 <0.01 162 Protein family/group databases
CAZy 3736 3231 0.01 120 Protein family/group databases
CCDS 49801 34866 0.09 51 Sequence databases
CD-CODE 10737 8222 0.02 100 Miscellaneous databases
CDD 394459 310231 0.69 16 Family and domain databases
CGD 2167 2150 <0.01 134 Organism-specific databases
ChEMBL 10744 10567 0.02 99 Chemistry databases
ChiTaRS 15286 15252 0.03 95 Miscellaneous databases
CIViC 563 562 <0.01 154 Organism-specific databases
ClinPGx 17968 17949 0.03 88 Organism-specific databases
CollecTF 140 140 <0.01 165 Gene expression databases
ComplexPortal 19536 9906 0.03 80 Protein-protein interaction databases
ConoServer 966 878 <0.01 148 Organism-specific databases
CORUM 8091 8091 0.01 108 Protein-protein interaction databases
CPTAC 3472 1929 0.01 121 Proteomic databases
CPTC 410 410 <0.01 157 Protocols and materials databases
CTD 77994 77338 0.14 41 Organism-specific databases
DEPOD 254 254 <0.01 164 PTM databases
dictyBase 4228 4114 0.01 117 Organism-specific databases
DIP 17585 17544 0.03 90 Protein-protein interaction databases
DisGeNET 17613 17415 0.03 89 Organism-specific databases
DisProt 2828 2802 <0.01 129 Family and domain databases
DMDM 16164 16163 0.03 94 Genetic variation databases
DNASU 48627 48548 0.08 53 Protocols and materials databases
DrugBank 37137 4996 0.06 60 Chemistry databases
DrugCentral 2983 2983 0.01 127 Chemistry databases
EchoBASE 4158 4158 0.01 118 Organism-specific databases
eggNOG 341051 335150 0.59 20 Phylogenomic databases
ELM 1815 1815 <0.01 138 Protein-protein interaction databases
EMBL 1029923 562643 1.79 3 Sequence databases
EMDB 149762 12771 0.26 31 3D structure databases
Ensembl 171226 51965 0.30 26 Genome annotation databases
EnsemblBacteria 55630 55452 0.10 48 Genome annotation databases
EnsemblFungi 19750 19432 0.03 79 Genome annotation databases
EnsemblMetazoa 19766 12962 0.03 78 Genome annotation databases
EnsemblPlants 26391 6359 0.05 66 Genome annotation databases
EnsemblProtists 1765 1618 <0.01 139 Genome annotation databases
ESTHER 3047 3044 0.01 126 Protein family/group databases
euHCVdb 56 45 <0.01 169 Organism-specific databases
EvolutionaryTrace 22750 22750 0.04 70 Miscellaneous databases
ExpressionAtlas 49591 49591 0.09 52 Gene expression databases
FlyBase 4033 3924 0.01 119 Organism-specific databases
FunCoup 143682 143682 0.25 32 Protein-protein interaction databases
FunFam 559471 328075 0.97 9 Family and domain databases
Gene3D 801829 479252 1.39 6 Family and domain databases
GeneCards 20377 20247 0.04 73 Organism-specific databases
GeneID 320009 294594 0.56 23 Genome annotation databases
GeneReviews 1647 1643 <0.01 140 Organism-specific databases
GeneTree 49805 49787 0.09 50 Phylogenomic databases
GeneWiki 10351 10269 0.02 102 Miscellaneous databases
GenomeRNAi 22327 22326 0.04 71 Miscellaneous databases
GlyConnect 2297 2286 <0.01 133 PTM databases
GlyCosmos 28912 28912 0.05 62 PTM databases
GlyGen 39908 39908 0.07 59 PTM databases
GO 3067341 551801 5.33 1 Ontologies
Gramene 26398 6363 0.05 65 Genome annotation databases
GuidetoPHARMACOLOGY 2344 2344 <0.01 132 Chemistry databases
HAMAP 331129 328192 0.58 22 Family and domain databases
HGNC 20382 20256 0.04 72 Organism-specific databases
HOGENOM 429233 429233 0.75 15 Phylogenomic databases
HPA 19350 19212 0.03 82 Organism-specific databases
IDEAL 1332 1332 <0.01 143 Family and domain databases
IMGT_GENE-DB 267 267 <0.01 163 Protein family/group databases
InParanoid 165081 165081 0.29 28 Phylogenomic databases
IntAct 59182 59182 0.10 46 Protein-protein interaction databases
InterPro 2608505 559985 4.53 2 Family and domain databases
iPTMnet 56794 56794 0.10 47 PTM databases
JaponicusDB 43 43 <0.01 172 Organism-specific databases
jPOST 28435 28435 0.05 63 Proteomic databases
KEGG 521645 485206 0.91 13 Genome annotation databases
LegioList 765 763 <0.01 151 Organism-specific databases
Leproma 672 669 <0.01 152 Organism-specific databases
MaizeGDB 529 525 <0.01 155 Organism-specific databases
MalaCards 7439 7426 0.01 109 Organism-specific databases
MANE-Select 18601 18487 0.03 85 Genome annotation databases
MassIVE 19139 19139 0.03 83 Proteomic databases
MDposit 2965 2965 0.01 128 3D structure databases
MDRepo 2104 2104 <0.01 135 3D structure databases
MEROPS 14278 13859 0.02 97 Protein family/group databases
MetOSite 3455 3455 0.01 122 PTM databases
MGI 17197 17154 0.03 91 Organism-specific databases
MIM 24353 16714 0.04 67 Organism-specific databases
MINT 24157 24157 0.04 68 Protein-protein interaction databases
MoonDB 348 348 <0.01 161 Protein family/group databases
MoonProt 368 368 <0.01 160 Protein family/group databases
NCBIfam 548388 347801 0.95 11 Family and domain databases
NDEx 10597 10597 0.02 101 Protein-protein interaction databases
NIAGADS 76 76 <0.01 167 Organism-specific databases
OGP 373 373 <0.01 159 2D gel databases
OMA 121453 121453 0.21 35 Phylogenomic databases
OpenTargets 18611 18467 0.03 84 Organism-specific databases
Orphanet 8294 4513 0.01 105 Organism-specific databases
OrthoDB 271371 271371 0.47 24 Phylogenomic databases
PAN-GO 20303 20303 0.04 74 Phylogenomic databases
PANTHER 966355 506621 1.68 4 Family and domain databases
PathwayCommons 19432 19432 0.03 81 Enzyme and pathway databases
PATRIC 93459 93459 0.16 39 Genome annotation databases
PaxDb 169503 169503 0.29 27 Proteomic databases
PCDDB 137 137 <0.01 166 3D structure databases
PDB 387742 39247 0.67 17 3D structure databases
PDBsum 387742 39247 0.67 18 3D structure databases
PeptideAtlas 44690 44690 0.08 56 Proteomic databases
PeroxiBase 795 774 <0.01 150 Protein family/group databases
Pfam 891269 553641 1.55 5 Family and domain databases
Pharos 20191 20191 0.04 76 Miscellaneous databases
PHI-base 2533 2003 <0.01 130 Miscellaneous databases
PhosphoSitePlus 42267 42267 0.07 58 PTM databases
PhylomeDB 115889 115889 0.20 36 Phylogenomic databases
PIR 125321 114974 0.22 34 Sequence databases
PIRSF 111210 110036 0.19 37 Family and domain databases
PlantReactome 1436 824 <0.01 142 Enzyme and pathway databases
PomBase 5135 5131 0.01 115 Organism-specific databases
PRIDE 637 637 <0.01 153 Proteomic databases
PRINTS 151925 130362 0.26 30 Family and domain databases
PRO 100246 100246 0.17 38 Miscellaneous databases
ProMEX 489 489 <0.01 156 Proteomic databases
PROSITE 498107 314236 0.87 14 Family and domain databases
Proteomes 379774 377384 0.66 19 Miscellaneous databases
ProteomicsDB 72990 45520 0.13 42 Proteomic databases
PseudoCAP 2081 2081 <0.01 136 Organism-specific databases
Pumba 18202 18202 0.03 87 Proteomic databases
Reactome 152397 39506 0.26 29 Enzyme and pathway databases
REBASE 808 399 <0.01 149 Protein family/group databases
RefSeq 573114 448029 1.00 8 Sequence databases
REPRODUCTION-2DPAGE 1260 1039 <0.01 144 2D gel databases
RGD 8167 8166 0.01 106 Organism-specific databases
RNAct 43123 43123 0.07 57 Miscellaneous databases
SABIO-RK 5996 5996 0.01 113 Enzyme and pathway databases
SASBDB 1080 1080 <0.01 147 3D structure databases
SFLD 27833 9162 0.05 64 Family and domain databases
SGD 6753 6748 0.01 112 Organism-specific databases
SignaLink 19947 19947 0.03 77 Enzyme and pathway databases
SIGNOR 8161 8161 0.01 107 Enzyme and pathway databases
SMART 207565 149682 0.36 25 Family and domain databases
SMR 528134 528134 0.92 12 3D structure databases
STRENDA-DB 59 45 <0.01 168 Enzyme and pathway databases
STRING 337709 337709 0.59 21 Protein-protein interaction databases
SUPFAM 653304 462797 1.13 7 Family and domain databases
SwissLipids 1478 1394 <0.01 141 Chemistry databases
SwissPalm 14336 14336 0.02 96 PTM databases
TAIR 16439 16345 0.03 93 Organism-specific databases
TCDB 8885 8786 0.02 103 Protein family/group databases
TopDownProteomics 3236 2957 0.01 124 Proteomic databases
TubercuList 2365 2329 <0.01 131 Organism-specific databases
UCSC 51160 46657 0.09 49 Genome annotation databases
UniLectin 385 385 <0.01 158 Protein family/group databases
UniPathway 140849 127160 0.24 33 Enzyme and pathway databases
VEuPathDB 88198 80548 0.15 40 Organism-specific databases
VGNC 5166 5154 0.01 114 Organism-specific databases
WBParaSite 56 54 <0.01 170 Genome annotation databases
WormBase 6940 5098 0.01 110 Organism-specific databases
Xenbase 4764 4764 0.01 116 Organism-specific databases
YCharOS 47 47 <0.01 171 Protocols and materials databases
ZFIN 3224 3222 0.01 125 Organism-specific databases
Total number of cross-referenced databases: 173
6. AMINO ACID COMPOSITION
6.1 Composition in percent for the complete database
Ala (A) 8.25 Gln (Q) 3.93 Leu (L) 9.64 Ser (S) 6.66
Arg (R) 5.52 Glu (E) 6.71 Lys (K) 5.79 Thr (T) 5.36
Asn (N) 4.06 Gly (G) 7.07 Met (M) 2.41 Trp (W) 1.10
Asp (D) 5.46 His (H) 2.27 Phe (F) 3.86 Tyr (Y) 2.92
Cys (C) 1.38 Ile (I) 5.90 Pro (P) 4.75 Val (V) 6.85
Asx (B) 0.000 Glx (Z) 0.000 Xaa (X) 0.00
Legend: gray = aliphatic, red = acidic, green = small hydroxy,
blue = basic, black = aromatic, white = amide, yellow = sulfur
6.2 Classification of the amino acids by their frequency
Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
Phe, Tyr, Met, His, Cys, Trp
7. MISCELLANEOUS STATISTICS
4471 entries are encoded on a mitochondrion, and 4074 are encoded on a plasmid.
12200 entries are encoded on a plastid,
of which 23 are encoded on apicoplasts,
11633 on chloroplasts,
51 on organellar chromatophores,
145 on cyanelles,
149 on non-photosynthetic plastids and
199 on unspecified types of plastid.
Number of entries with at least one sequence correction: 81782
