Short- and long-term effects of chromosome mis-segregation and aneuploidy
Author(s)
Santaguida, Stefano
Amon, Angelika B
Date Issued
July 2015
Journal
Nature Reviews Molecular Cell Biology
Publisher
Nature Publishing Group
Citation
Santaguida, Stefano and Angelika Amon. “Short- and Long-Term Effects of Chromosome Mis-Segregation and Aneuploidy.” Nature Reviews Molecular Cell Biology 16, 8 (August 2015): 473–485
Version
Author's final manuscript
Abstract
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellular consequences of CIN and aneuploidy. Chromosome mis-segregation per se can alter the genome in many more ways than just causing the gain or loss of chromosomes. The short- and long-term effects of aneuploidy are caused by gene-specific effects and a stereotypic aneuploidy stress response. Importantly, these recent findings provide insights into the role of aneuploidy in tumorigenesis.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nrm4025
