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. 2020 Sep;81(9):482-484.
doi: 10.1016/j.humimm.2019.06.006. Epub 2019 Jun 11.

Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa

Stephen Clayton  1 , Rodrigo Barquera  2 , María Guadalupe Uribe-Duarte  3 , Isis Goné Vázquez  4 , Joaquín Zúñiga  5 , Esteban Arrieta-Bolaños  6 , Diana Iraíz Hernández-Zaragoza  7 , María de Jesús Ruíz-Corral  3 , Araceli Escobedo-Ruíz  4 , Francia Paulina Arellano-Prado  8 , Víctor Eduardo García-Arias  8 , Marla Estefanía Rodríguez-López  8 , Alicia Bravo-Acevedo  9 , María Guadalupe de Jesús Sánchez-Fernández  10 , Jesús Abraham Aguilar-Campos  3 , Ricardo Serrano-Osuna  3 , Benjamín Gómez-Navarro  11 , Mario J Sandoval-Sandoval  12 , Edmond J Yunis  13 , Carolina Bekker-Méndez  14 , Julio Granados  15
Affiliations

Genetic diversity of HLA system in two populations from Sinaloa, Mexico: Culiacán and rural Sinaloa

Stephen Clayton et al. Hum Immunol. 2020 Sep.

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 286 Mexicans from the state of Sinaloa living in Culiacán (N = 103) and rural communities (N = 183) to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes for the state of Sinaloa include ten Native American most probable ancestry and five European most probable ancestry haplotypes. The admixture estimates revealed that the main genetic components in the state of Sinaloa are European (62.39 ± 3.47%) and Native American (37.61 ± 2.85%), while the African genetic component was estimated as virtually absent (0.00 ± 1.86%).

Keywords: Admixture; HLA; Immunogenetics; Population genetics; Sinaloa.

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