Plague Inc. (Video Game)

"This is what you guys get for not washing your hands!"

— Thinknoodles, "This Game GOT BANNED In China! | Plague Inc | Fan Choice FRIGHTday"

Plague Inc. is a real-time multi-platform strategy simulation video game created by the British James Vaughan and developed by his studio Ndemic Creations. A Spiritual Successor to the web game Pandemic, the game was first released as a Mobile Phone Game on May 26, 2012 for iOS, later being ported to Microsoft Windows and Android on October 4 of the same year, and the Microsoft Phone on May 13, 2015. An Updated Re-release for PC (on Steam) titled Plague Inc: Evolved, including all of the original game's expansion packs released up to then, was first released on Steam Early Access on February 20, 2014, with later releases up to February 18, 2016 making it available on Windows, Mac, Linux, the Xbox One, and the PlayStation 4. It was also ported to the Nintendo Switch on August 2, 2019, and the Xbox Series X|S and the PlayStation 5 on 2020.

Each game revolves around you creating a disease with an end goal of total annihilation of the human race by evolving a deadly, global plague whilst adapting against everything humanity can do to defend itself. After choosing your initial pathogen type for the disease (each of which is characterized by different functions and gameplay dynamics), you are brought to the world map, where you freely pick your starting location.

It's more strategical in the sense that certain countries have perks that make them easier or harder to infect; for instance, rich nations have better health care, while third-world countries are far easier to overtake with infection. Like Pandemic before it, certain countries are harder to infect than others. To list:

Caribbean, New Guinea, the Philippines, and Madagascar: Their one port is frustrating.
Iceland: Tough to get to despite having both a port and an airport.
New Zealand: Good healthcare and low population density means a slow disease spread without Rodent Transmission or Drug Resistance.
Greenland: This country is a bastard to infect since it has one port and a very small percentage of ships go there. And if one does get there? Good luck infecting more than 10 people without Cold Resistance. It also applies on the flip-side, as starting in Greenland (or its only neighbor, Iceland) means you have to work through plenty of the healthiest and smallest countries on the map to infect much of anywhere else.
Canada: Its cold climate, good healthcare, no rural/urban bonus, and scattered population make it a pain to infect.

Over the years, various Downloadable Content packs were created as expansions for the game:^note

The Neurax Worm (added July 15, 2012 with the Mutation 1.3 update) is the first of a series of pathogen types known as "Special Plagues". It's a pathogen that prioritizes mental illnesses (depression, aggression, subjugation, etc.) over typical symptoms.
The Necroa Virus (February 26, 2013 with Mutation 1.5) is a Special Plague that promotes a Zombie Apocalypse scenario once you start killing humans, where you get to command zombies (somehow).
The Scenarios game type (November 25, 2013 with Mutation 1.7, with further updates adding more scenarios) throws you into... well, scenarios, where your disease and/or Earth have been tweaked according to the scenario in question, such as playing as real-life diseases like Smallpox or The Black Death, playing in alternate universes like a world where every country's traits are reversed (i.e. Egypt becomes cold, the USA becomes poor, etc.) or a world severely affected by Global Warming, etc.
The Simian Flu, a tie-in with Dawn of the Planet of the Apes inspired by the Creative Closing Credits of Rise of the Planet of the Apes (July 10, 2014 with Mutation 1.9), is a Special Plague where the player must not only infect and annihilate humanity, but also control intelligent apes to assist the spread of the disease in order to give control of the Earth to the apes.
The Custom Scenarios (November 2014 as early access on Evolved; April 22, 2016 in full-force for both versions), downloadable fan-made scenarios made with a Level Editor known as the "Scenario Creator".^note
A vampire disease known as the Shadow Plague (October 24, 2016 with Mutation 1.13), where a dormant vampire awakens in modern times to make the billions of humans its slaves, combining elements from the past three Special Plagues: the Neurax Worm, the Necroa Virus, and the Simian Flu.
On March 24, 2020, in response to a invokedresurgence of popularity caused by the COVID-19 Pandemic, Ndemic Creations announced a DLC titled The Cure, defined by its addition of the titular alternate Cure Mode, which reverses the very premise of the main game in that the player manages an international health organization to save the world from a plague. The player still gets to choose the pathogen type for the disease they're fighting against, though. After being briefly teased on Ndemic Creations' YouTube channel on October 20, 2020, The Cure was officially released on November 10, 2020 for the original Plague Inc., with the Evolved version arriving on January 29, 2021. The creators stated that the mode would be available for free until the COVID-19 pandemic is under control. The DLC ceased to be downloadable for free on July 1, 2022, now requiring separate purchase for both versions.
Outbreak Mode (added with a free update on November 24, 2025 for the original game, and December 15, 2025 for Evolved) is a game type for the main game that involves a variety of "outbreak" games that alternate in availability over a live cycle of 24 hours, each of which features a selection of modifiers that alter the gameplay mechanics of the regular main game.
The Xenolith (April 7, 2026 with the Aliens & Anti-Vaxxers DLC) is an alien substance that came to Earth in a meteorite and gets to work transforming the planet itself into crystal, as well as any humans that try to get in its way.

A successful Kickstarter was launched for a tie-in board game named Plague Inc.: The Board Game, which ended up being over 1000% funded by the end of the campaign, and was released on April 3, 2017.

You can download the original game's iOS version here, and the Android version here.

In November 2024, a sequel named After Inc. was released on iOS and Android, which is set decades after the successful extermination of most of humanity by the Necroa Virus, and the survivors come out of bunkers to try to rebuild.

WARNING - Trope Virus Identified:

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#-D

Acceptable Breaks from Reality: Evolving a new feature causes it to spontaneously develop in the infection everywhere. In real life, this mutated strain of the pathogen would have to out-compete the original before becoming dominant, but re-infecting the world every time you make a change would be incredibly tedious and unfun.
Adam and Eve Plot: Referenced and implied with this official T-shirt (part of which is pictured in the trope's page) with only two people cured, no infected, and everyone else dead. Along with an implied Cardiovascular Love-type Heart Symbol:
Looks like it's just you and me...
Adam Smith Hates Your Guts: On Mega-Brutal, the cost to evolve symptoms increases the more people you infect.
Adaptational Badass: The Simian Flu. In Dawn of the Planet of the Apes and its supplementary tie-ins, the apes being capable of infecting humans with ALZ-113 was a mere rumour which nonetheless got humans riled up against the apes before and after the collapse of human civilization; it's also implied the virus spread between apes and humans separately. In this game, however, you can evolve an ability which allows the apes to transmit the virus to humans and vice versa.
Adaptational Heroism: Gen-Sys, of sorts, in the Simian Flu. In the novel tie-in between Rise and Dawn, it's revealed the company tried to cover up its own involvement in the virus creation, going as far as renaming the pathogen to distance themselves away from it and hiring hitmen to silence their own personnel (something that is heavily implied to have happened to Will Rodman, the protagonist of Rise) before getting exposed by a journalist and thus getting forced to cooperate. Here, Gen-Sys acknowledges its role in creating the pathogen right off the bat and tries its best to cure it.
Adaptational Villainy: The Apes in the Simian Flu. In Rise of the Planet of the Apes, the virus was spread by a careless researcher who then passed it to an equally irresponsible airplane pilot, but the apes were innocent and were at worst defending themselves. In fact, the only time an ape (Koba) got a human infected with ALZ-113 happened by sheer accident. Here, the apes openly seek to spread the virus among humans.
Affectionate Parody:
- Of Pandemic, eventually evolving into a respectable Spiritual Successor.
- It parodies Real Life events, switching names around at times (e.g.: Gill Bates wants to send scientists into space to find a cure).
Anti-Frustration Features:
- The Fungus has a series of "Spore Burst" abilities that allow it to infect a random country, allowing for more aggressive play since islands are less of a concern.
- Extreme Zoonosis can allow a plague to infiltrate an island that has shut all of its ports.
- The special plagues have some unique abilities that make ports outright useless in stopping a pandemic, since an infection can actively be sent to a country.
  - A couple commonplace ones in some Custom Scenarios, usually to decrease the odds of the scenario being unwinnable due to a country shutting everything down.
  - Including a "Spore Burst" equivalent to instantly infect a locked country.
  - Cranking up Infectivity to increase the odds that every country will be infected before they can react.
  - Giving problem countries alternate entrances, like giving airports to problem islands, in order to ensure that their usual entrance being locked doesn't immediately mean game over.
Anyone Can Die: Well, everyone can die. And should. Unless you're playing Cure mode, where your goal is to avert this.
The Apocalypse Brings Out the Best in People: All of humanity fights to the bitter end to find a cure, even if you've managed to infect enough people that society has basically collapsed and things will never be the same again. It's heavily implied that wars and tensions between nations, even in case where bad blood has existed for years, are all set aside (if not outright resolved) for the sake of stopping the plague from destroying the world.
Apocalypse How: Planetary Human Extinction is your goal. (Although the victory screen insists a Class 6 has occurred.) You can still get Regional and Continental Extinctions (which would effectively mean Global Collapse or Disruption, at the very least) if Humans successfully fight back. Even if you're very unlucky, the spread of your virus is guaranteed to cause Regional Disruption with all the closures and emergency measures. One of the Xenolith's endings results in a Class X, with the entire planet exploding into infectious shards.
Apocalyptic Log:
- The news reports, as they track infections and lockdowns across the globe. By the endgame there's usually a clear progression from "New disease spotted" to "Countries enact increasingly extreme measures to curb disease" to "All life in [Country] has been destroyed" in the news ticker.
- Plus the ''Evolved'' trailer and introduction where an increasingly-worried doctor (voiced by Harry S Robins, AKA every scientist in the Half-Life universe, including Dr. Kleiner) narrates an autopsy of a woman with the PAX-12 virus, ending in a facility lockdown when he realizes the deceased may still be infectious.
Arson, Murder, and Jaywalking:
- Common with mutations, especially near the end-game. You may have given your disease Total Organ Failure, Necrosis, Immuno-Suppression, Internal Hemorrhaging, and a bunch of other highly lethal and really painful symptoms, only for it to spontaneously evolve something like Sneezing.
- In Cure Mode, the Bio-Weapon's listed symptoms (aside from its two abilities) are, clockwise from bottom left: Total Organ Failure, Internal Haemorrhaging, Subconjunctival Haemorrhage^note, Necrosis... and Coughing.
Artificial Limbs: One scenario involves humanity developing and mass-producing artificial organs. They actually do slow down the death count when you start killing...until you evolve Insanity and Hypersensitivity, at which point you'll earn a lethality bonus from infectees ripping out their organs.
Artistic License – Biology: Strongly averted most of the time.
- Asked if he was worried that real-life terrorists might use the games to model bio-terror attacks, Ndemic Creations founder James Vaughn said he hoped they did - their plans would be neutered by the game's bent towards making good entertainment. Infecting the world, or any nation, is easier than it would be in reality, but the biggest shortcut is the way that when you "evolve" a new feature, it spontaneously develops in the infection everywhere. Vaughn compared this to a baby being born with six fingers on each hand meaning that everyone on Earth suddenly grew extra fingers. The new strain would have to out-compete the old one to become dominant, but re-infecting the whole world every time you made a change would be no fun.
- Parasites do not directly kill their hosts under most conditions but feed off them instead. How parasites operate in-game resembles more of a parasitoid, which can kill its hosts eventually.
- Due to the use of generic descriptions of events and traits, all pathogens possess DNA and DNA points for evolution, including the decidedly non-DNA-owning prion. Real-world prion diseases are also impossible to cure due to being malformed proteins accumulating in the brain, while the Plague Inc. version can be.
Artistic License – Geography:
- National borders are simplified and some neighbouring countries are combined into one (such as Denmark and Germany, or UK and Ireland). The fact that Alaska is considered part of Canada is even lampshaded in the news ticker.
- The world is modelled as a flat map so there are no planes or ships that cross the Pacific Ocean for fear of going off the edges.
- Plague Inc.: Evolved introduces City Cams for each country; yet some of these have disrepancies.
  - China's City Cam shows a district in Tokyo, Japan.
  - Central Europe's City Cam shows a river bank in Frankfurt, which located in Germany. In addition, it features a fictional bridge that has been edited specifically for this game. To make matters weirder, an earlier version of the PC port had Central Europe's City Cam for a majority of other countries, including Ukraine, Baltic States, Australia, Sweden, Iceland and even Greenland.
  - UK's own City Cam also features a fictional bridge.
  - Middle East's City Cam is located in Dubai, even though Dubai is located in UAE, which is not part of the Middle East.
Artistic License – Military:
- One of Russia's City Cams shows an M47 Patton Tank from the USA. The same is true for Kazakhstan's City Cam feed.
- Iceland's City Cam also shows a tank and helicopters which are all used by the US military.
- The Caribbean City Cam shows a HAL Dhruv helicopter, which is used by the Indian military.
- One of Canada's City Cams depicts a Chieftain tank, which is used by the armed forces of the United Kingdom and some Middle Eastern countries.
Ascended Meme:
- Ndemic actually ended up making shirts expressing hatred of Greenland.
- One of the most common things to do in Custom Scenarios is to give Greenland (and sometimes other hard-to-reach countries) an airport. Enter Mutation 15 and the "Flight Club" official scenario, in which every country has an airport.
  "Does the idea of Greenland getting a major airport excite you?"
- An official scenario, Greenland International, not only gives Greenland an airport, but also makes the country very rich.
- One of the official scenarios is called "Shut Down Everything", and Madagascar is noticeably richer than normally.
Assimilation Plot: You can do this with the Neurax Worm. The Christmas scenario outright requires it in order to win.
Attack Drones:
- Governments will use these in the Simian Flu plague type to scout out and destroy ape settlements. You have no option but evade them.
- In the Shadow Plague type, the Templars will send drones to destroy your vampire lairs. This time, you can fight back and destroy them with Blood Rage.
Autocannibalism: The Autophagia symptom, which "compels Infectees to bite and devour their own bodies".
Awesome, but Impractical: Plagues that have high Lethality like the Bio-Weapon and Black Death/Bubonic Plague. You get to kill people from early on but it also means that in the early game those who are infected can easily die before infecting anyone else, causing the pathogen to kill itself. In addition to this, these plagues can easily cause high Severity and prioritization to find a cure.
The Bad Guy Wins: The goal of the game and what will happen upon your pathogen's victory. Unless it's the Christmas Scenario where your Neurax Worm is less of a villain and Ultimate Board Games, where there is no villain at all.
invokedBanned in China: Rarely, governments may take action against your disease by banning Plague Inc. In-Universe.
Bat Out of Hell: The Necroa Virus and Nipah Virus allow bats to transmit infection and, at higher levels, kill. This is also all over the place in the Shadow Plague mode, where the vampire can turn themselves into a bat to fly between countries.
Bittersweet Ending: Should humanity manage to survive your disease and successfully cure it after it wipes out a lot of people, then this trope happens. Curing and eradicating your disease means that humans will endure, but at a very great cost to human life, economic ruin, and psychological trauma. While your disease lost, it still left behind a very messed up world. Even as your disease gets cured, messages of surviving humans facing a "changed world" will drive this point home.
The Black Death: A Scenario allows for modern-day replication of the famous pandemic.
Blatant Lies: One of the news ticker items involves a "Green tech firm" that claims to invent a power source fueled by "laughter and joy". The firm also "denies reports of oil barrels nearby".
Body Horror: Yup.
- The Frozen Virus, Necroa Virus, and Neurax Worm scenarios are the main offenders, with their lovingly detailed descriptions and visual depictions of the plague's effects on human bodies.
- Also, a game about infecting the world with a deadly illness wouldn’t be complete without the vast selection of horrific symptoms you can pick from to increase its infectivity, lethality, and severity. While you thankfully never get to see what your victims look like, just try and not to visualize Necrosis or the Profuse Bleeding combo, and try not to get absolutely disturbed by the imagery of heavily bleeding, abscess-riddled, gangrenous people stumbling around town as their organs are shutting down.
Bragging Rights Reward: Unlocking cheats requires beating the game with every disease type on Brutal difficulty or higher, thus proving that you've mastered the game without needing cheats at all. Ironically, some cheats make the game harder to beat, like re-shuffling the sympthoms or giving you several of them from the get-go. So, if you happen to get Total Organ Failure when you just started the game, well...
Brainwashing for the Greater Good: What the Neurax Worm intends and believes during the Christmas Scenario, where it is illegal to be happy and misery is enforced.
But What About the Astronauts?: You can avert this if the cure gets sent to space, where the plague infects and kills them. It's hard, though, and also a very rare of event to begin with.
Captain Ersatz: The Xenolith from the Aliens & Anti-Vaxxers DLC is obviously a copyright friendly version of Tiberium: a green alien crystal that arrived on Earth via meteor, converts anything it touches into more of itself, and slowly xenoforms the planet into an inhopistable alien landscape.
Chekhov's News: In-universe, since the player already knows what will happen, the news updates at the top become meaningful later.
Clash of Evolutionary Levels: Happens in the Simian Flu (humans vs. evolved apes) and Frozen Virus (humans vs. humans regressing into Neanderthals) scenarios.
Color-Coded for Your Convenience: Countries will go from the natural green and yellow landscaping to red for regular plagues, orange for the Neurax Worm (pink for the Cuddle Bug scenario), purple-blackish for the Necroa Virus, violet for the Shadow Plague, and green for the Xenolith, as more of the world's population becomes infected. When you start killing people, these colors will become an increasingly darker shade as the death toll rises. The Simian Flu is an interesting case, since it offers a dual perspective of having the plague be colored yellow for humans and green for apes, with the ability to switch the modes.
Composite Character:
- The Shadow Plague combines gameplay elements from the Neurax Worm, the Necroa Virus and the Simian Flu, such as an ability to move an infection-causing entity from country to country, the need to balance the plague's effects on two different groups, and symptoms that act as an Instant-Win Condition when all humans are infected.
- Mad Cow Disease combines the key disadvantages of the Black Death and Smallpox, starting out with a very high severity and lethality due to its pre-loaded symptoms.
Controllable Helplessness:
- Possible if an island country shuts down all ports and airports before it becomes infected (and there's no workaround like Trojan Planes or Spore Burst); you can keep playing until everyone else is dead, but outside of a very, very rare event that comes with the Tier 3 mutation-boosting transmissions^note, the run is already over.
- Similarly, the completion of the cure isn't an instant game over—you get to watch the "Infected" count tick down for several seconds before getting the defeat screen. And if you're doing Shadow Plague, a few extra seconds as your vampire is forced to feed on cured people and is quickly poisoned to death. However, this has the beneficial side effect of giving you time to acquire a Genetic Reshuffle, which will set back the cure and give you the opportunity to clutch the round.
Crack Defeat: The "Ultimate Board Games" scenario has one of these. The "Infected" tab is replaced with "Interested" and the "Dead" tab is replaced by "Purchased." The goal is to sell as many games as possible. However, if "Interested" reaches zero, it is treated as a defeat since no one is interested. That would include if everyone was in the purchase column. So selling enough board games so that everyone in the world buys it (the goal of the scenario) will actually cause a defeat.
Creepy Good: The Neurax Worm in the Christmas scenario. Storywise, it's attempting to spread joy and happiness with the goal of Saving Christmas... using many of the same Mind Control tactics as a normal Neurax Worm run. However, it's completely impossible to increase Lethality, and even natural disasters are disabled.
Current Events Blog: Sort of. News come in real time, so the news bar is akin to this.
Curse of the Pharaoh: Due to the Multiple-Choice Past of the Necroa Virus, one of the possible origins is from an ancient pyramid. Justified Trope, as said pyramid was built precisely to contain the Necroa Virus, and had been inscribed with many warnings which of course archeologists had ignored. If the player does not do anything when the origins get uncovered, human researchers eventually learn of a way to paralyze zombies through striking certain points of the skull.
Cutting Off the Branches: Within the context of After Inc. as its official sequel, Necroa Virus is the leftover branch, specifically the defeat ending.
Damn You, Muscle Memory!:
- In some custom scenarios, official scenarios, or outbreaks where they change a country's setting (e.g. Global Warming makes some previously Cold countries neutral, Sovereign Default makes the USA and the UK Poor instead of Rich and making Saudi Arabia Rich instead of neutral, and Climate Chaos and Wealth Transfer makes every Hot and Cold country and Rich and Poor country swap wealth status respectively), it's possible to still keep to your main game gameplan (e.g. Getting Cold Resistance to spread easily throughout Russia to get into Greenland in Climate Chaos and therefore forgetting in that particular Outbreak, you need Heat Resistance instead) only to wonder why are some countries not getting infected as fast.
- If the Outbreak Challenge you're playing that day happens to have a modifier where popping an orange DNA bubble will kill or cure the target country's infected population, it is very easy to forget this fact and automatically pop the first orange bubble that appears, immediately ending the run.
Day of the Jackboot: The whole world in the Christmas scenario. Having fun and being happy are literally illegal, and humanity is made to be bored and miserable by law and coercion. It's so bad that even the Neurax Worm is compelled to save the day... by mind-controlling everyone into being cheerful.
Dead Weight: Further symptom upgrades for the Necroa Virus allow some zombies to become living bombs by building up flammable gas and rot-juice.
Deconstruction:
- The game as whole deconstructs the general The Plague trope. If a disease is too lethal, it will kill its hosts before they can spread it, which eventually will stop the plague by itself. It is most pronounced in the Bio-Weapon scenario. The plague is caused by a weaponised form of an already highly lethal disease. Too lethal, in fact: it kills people too fast for them to spread it, which is why slow-acting but otherwise highly unpleasant diseases are used instead.
- Ebola is horrific, but wipes out people before they can leave town to spread it to the airport.
- Anthrax lingers for ages before actually making your lungs rot, but the carrier has spread it to everyone they met. Maybe to two or three airports and a seaport.
- The "Herd Immunity" scenario plays things a bit more realistically, with some people being able to recover from the disease on their own thanks to having immunity. Therefore, the goal goes from "kill everyone in the world" to "let as few people recover as possible".
Delayed Reaction: This is the weakness of the Prion type diseases, taking longer time to react to new evolutions and thus a delay before a purchased evolution takes effect.
Determinator:
- The world will not stop cure research until every nation's government falls, which may happen at a surviving population of half a million or less, all infected with something that causes every symptom from organ failure to comas to rapid bleeding.
- Often, the country leading the research will continue to fly study missions around the world even when it seems all hope is lost and the world is virtually dead.
Developer's Foresight: For the Shadow Plague:
- Normally if you evolve Shadow Blessing, your pathogen will get discovered quickly soon after thanks to the intense bruising on the infected. However, if you enable the No Government Action cheat and then subsequently the Templars set one of their fortresses in a country with infected people, they will be the one to realize you have released the pathogen instead of the usual diagnostic team.
- Normally if you win via the Shadow Slaves symptom, the endgame message says: "and now, after thousands of years, the vampires can finally begin their rule of blood and pain." If however, all your Vampires are dead, it instead adjust the text to include "Soon, a new vampire will rise and it can begin its rule of blood and pain."
Devolution Device: Though a lot of the symptoms of the Pithovirus scenario are realistic, some of them start causing humans to mutate into Neanderthals. Infect everyone once you have this trait and it's a nonlethal win for destroying human civilization, just like the alternate Neurax Worm win.
Death by Disfigurement: Some high-lethality symptoms also heavily disfigure the victim. Evolving lethal symptoms in the Frozen Virus causes this as part of the Devolution Device plot listed above.
Denser and Wackier: The Shadow Plague, in which any science or pseudoscience was dropped in favor of evolutions that do stuff like morphing to bats, vampire lairs, and outright teleportation.
Disaster Relief Game: The main game is an inversion of this genre, wherein the player creates and spreads a plague disease around the world to infect all of humanity and ultimately drive it to extinction. The Cure's Cure Mode, on the other hand, is a straight example in which the player is put in the shoes of an international health organization and has to save the world from a disease styled like that of the main game.
Do Well, But Not Perfect: The game makes a point of teaching you this behavior with the Lethality and Severity mechanics. If your disease is sufficiently and overtly dangerous, the world's governments will begin working on cures to stamp you out faster, which encourages players to be subtle and play the long game, instead of going ham with their most deadly effects right away. Sure, making a virus or disease that debilitates and kills at a rapid pace is great for racking up a tidy bodycount initially, but all of the sick and dead people after the first few waves do raise a lot of alarms and nations will begin their quarantine measures, thus limiting your means of transmitting your plague to other locations. Dead people also don't tend to work very well as transmission vectors without investing into more overt infection methods, which will attract attention all the same.
Dude, Not Funny!: "Mankini is not funny, says Kazakh professor."^noteA reference to Borat.
Dung Fu: Evolving both Scouts and Excrement as the Simian Flu unlocks the Rude Awakening combo, allowing infected apes to fling their feces at uninfected ones, increasing transmission.

E-K

Earth-Shattering Kaboom: One of the Xenolith's endings, caused by dropping enough meteors, ends in the Earth exploding into infectious shards.
Easy Level Trick: On normal difficulty and below, the majority of scenarios can be won easily by immediately devolving any random symptoms your pathogen develops, thus keeping it under mankind's radar until it has infected absolutely everyone. Then use your accumulated DNA points to evolve a kill switch symptom or three and watch humanity go from 8 billion to extinct in just a few weeks, far too fast for the Puny Humans to come up with a cure.
Easy Logistics: Once the cure is complete, it will be deployed worldwide immediately, regardless of how badly your disease has ravaged the world. The eradication of smallpox took several years of concerted effort, but a slow, grinding defeat would be no fun for the player. Even if global society has collapsed (or fallen under the influence of the Neurax Worm), the disease will be eradicated within weeks or days. Of course, the same is also true for the disease, in that the infection changes globally in mere seconds after upgrading it.
Easy-Mode Mockery:
- There's an option in the settings menu called "Pity Mode" that, when active, will allow you to unlock the next disease type by winning on Casual difficulty instead of Normal.
- The Earth-Shattering Kaboom ending for the Xenolith (start with Star Shards, fully upgrade Gravimetric Tether, and use it on the same country five times in a row) requires the least amount of investment to achieve, but also results in a very poor final score if the game ends this way.
Elite Zombie: Certain combinations of Symptoms and Abilities can enable certain kinds of these; symptoms do stuff like increase bone, skin, and muscle density to make zombies harder to kill, hit harder, and run faster, mutate the salivary glands to make zombies gob acid, and build up flammable gasses and garbage juice to make them explode violently. It also mentions the Horde Master subtype. One symptom also turns freshly-reanimated corpses into Trap Zombies.
Enemy Summoner:
- Z-Com in the Necroa Virus scenario. Not only can they attack and kill zombies in the countries their bases are in, they can also send forces to establish bases in other countries should a base last long enough.
- The Templars in the Shadow Plague scenario. Should your vampire keep attacking a country long enough while there's at least 1 Fortress on the map, the attacked country will invite the Templars to build a new base.
Everybody Lives:
- If you screw up. On lower difficulties you'd have to try to fail to achieve this. On Brutal and Mega Brutal, this is most likely your Game Over if you don't increase Lethality soon enough.
- The Neurax Worm plague type and the Frozen Virus scenario are both capable of being won non-lethally if you're so inclined, and the mechanics practically encourage this since the same symptoms that cause this also set back or slow down the cure. In theory, the Shadow Plague could be won with Shadow Slaves alone without killing anyone, but not only would you have to never use Blood Wraith which will severely limit how many DNA points you can get, your vampire would have to be constantly on the move since even staying in a country is lethal as the vampire feeds.
- Inevitable in the "Santa's Little Helper" scenario and its temporary counterpart "Cuddle Bug"; not only is there no way to increase Lethality, but natural disasters are disabled, so it's literally impossible for anyone to die.
- Doable in a rather Non-Standard Game Over (though you still get the normal Defeat screen) with the Simian Flu, and there's an Achievement for it. You have to make all Apes intelligent (every single one on the planet, that is), let no more than 60,000 of them die, kill no humans and get no increases to Severity, and allow the disease to be cured. The result? With no more fear of disease, humans and evolved apes can coexist in peace, and you get the Achievement "The Future Is Bright".
- "Ultimate Board Games", as a consequence of being less of a plague and more of a marketing plug.
- Downplayed in the "Fake News" scenario; you're not actively killing anyone, and death isn't a tracked stat in this scenario; but there's no guarantee that people aren't dying as a consequence of your fake news (especially if you went for something like Scientific or Medical when drawing up your manifesto).
Evolution Power-Up: Certain Transmission Vector upgrades, typically those involving animals and blood, increase the chance of your pathogen randomly mutating symptoms.
Expy: Darkwater seems to be very heavily inspired by Resident Evil's Umbrella Corporation, being an amoral company who develop a zombie virus as a bioweapon then start scrambling to cover up the outbreaks it causes when it gets out of control.
Fate Worse than Death: Several diseases have special winning conditions that do not require killing off every last man, woman and child on the planet... But to all of them death may actually be preferable:
- Shadow Plague makes the vampires rule the Earth, while all of mankind is reduced to feral state, worshipping the vampires as gods and wanting nothing more than to bleed themselves for their masters, in hopes that one human in millions will be reborn as a vampire upon death. Any who do not will just be the first to be sacrificed.
- Frozen Virus can evolve humans back to Neanderthal state, destroying all of their emotional and logical capabilities, essentially turning mankind into mindless apes with no hope to ever evolve back.
- Neural Worm makes humans a slave species who only think they are more or less free; instead, mankind becomes a single Hive Mind and a gargantuan super-colony for the worm, to be used as the Puppeteer Parasite worms see fit, praising the pathogen as their eternal god, unable to ever regain independent thought.
Find the Cure:
- This is what mankind will eventually scramble to do and what you should prevent by keeping a low profile until the time is right, actively sabotaging the efforts, or a combination of the two.
- Appropriately enough, the overarching goal of The Cure is to create a cure for the plague currently spreading across the world. It's possible, though difficult, to win without one.
Flying Dutchman: Averted. No ships set sail when ports are closed, and already-sailing ships will dock instead of endlessly sailing around the world.
Foreshadowing:
- After evolving the first lethal zombie symptom in the Necroa Virus, news in yellow foreshadows the zombie outbreak, such as:
  - "Mother claims "dead" son tried to kill her."
  - "Bath salts blamed for cannibalism surge."^note
  - "Parents vanish, leaving small child alone."
- The Frozen Virus foreshadows human devolution with the early evolve Abilities as well as the last part of the scenario description ("Does it have what it takes to send humanity back to the stone age?").
Funny Background Event: The news bar spits out random non-disease-related headlines, especially early on. The amusing ones are usually either Ripped from the Headlines, a Shout-Out, a Take That!, or a basic two-phrase joke. They become much rarer once your plague progresses, due to the more pressing news stories.
"XmL_3rr0R$/?$-HELP.i.am.trapped.in.the.newsbar!.^"
"Cartoonist found dead at home. Details are sketchy"
Gameplay and Story Integration: Nigh everything in the world can be attributed to the disease, such as the London/Rio/Tokyo/Los Angeles Olympics infecting the UK/Brazil/Japan/USA and, Apple$oft tech advancing a cure, among others. This also includes natural disasters such as earthquakes, tsunamis, floods, and severe thunder storms. That's right, the death toll from an earthquake is attributed by the game to your disease. At least, the deaths don't trigger the same panic as a death from the disease.
Getting Smilies Painted on Your Soul: The Neurax Worm decides to take on the Christmas Scenario's Crapsack World by infecting every single person and forcing them to be happy.
Godzilla Threshold:
- As deaths pile up, countries will begin increasingly desperate measures to try to contain the spread of your plague. After a certain point, they will start experimenting on people, executing sick people, and even bombing their own cities if things get bad enough.
- In Cure Mode against the Bioweapon, since you are dealing with a potential extinction-level event, you yourself have access to a panel of such measures. As such, you can declare that this is the Armageddon for a massive authority boost, warn that you will not be able to save every country, and "extreme measures". It allows your field operatives to execute any and all infected so that they cannot spread the bioweapon any further. It is the only way of preventing an early outbreak.
Good Colours, Evil Colours:
- Failing a scenario (by your plague being wiped out before killing everyone) gives a white/light blue results screen. Succeeding a scenario by wiping out everyone (or achieving an alternate win condition) gives a dark red results screen.
- The reverse is true in Cure Mode; white/light blue if you win, dark red if you lose.
Gone Horribly Right:
- The Artificial Organs scenario has humans use artificial organs to reduce your plague's lethality. But if you evolve Insanity, the infected people will tear their artificial organs out and cause lethality to skyrocket.
- The teleportation scenario features the titular teleports to evacuate people from an infested country to a healthy one. But with enough severity and lethality, you can have a teleportation attempt end in failure and keep country population in their place.
Gone Horribly Wrong: One variation of the Necroa Virus' backstory indicates it was originally an AIDS-curing virus that mutated into something terrible.
Gradual Grinder: Fungus-based plagues have this due to their low transmission rate. Most of your infectivity is going to come from very direct connections unless you use Spore Burst, and keeping a low profile until you're ready is key.
Guest Fighter: As a result of the partnership between Ndemic and 20th Century Fox, the new plague in Mutation 1.9 arrives as the Simian Flu from Dawn of the Planet of the Apes.
Happiness Is Mandatory: Inverted in the Christmas scenario, where happiness is banned.
Harder Than Hard: Mega-Brutal difficulty: "For those who thought Brutal was Casual." Genetic drift will cause symptoms to become more expensive the more people you infect, random medical checkups will make a Stealth-Based Mission outright impossible, as your disease will be immediately discovered at a certain point, and doctors also invest in research, making cure progression faster.
Heel–Face Turn: If the US backstory of the Necroa Virus is triggered, the virus' creators (a corporation named Darkwater) eventually admit they made it and start looking into ways to combat it.
Hello, [Insert Name Here]: You get to name your disease. Or the opposing disease, in The Cure.
"Help! Help! Trapped in Title Factory!" A news ticker update may sometimes say: "Xml_3rr0R$/?$-HELP.i.am.trapped.in.the.newsbar!.^".
Hero Antagonist: Naturally, the various organisations that fight your disease and try to prevent you from killing everyone like the WHO, the CDC, Z-Com and the Templars.
Hiroshima as a Unit of Measure:
- You get messages saying that your disease has infected more people than Tuberculosis, HIV, the Black Plague, and the Common Cold, and that your disease has killed more people than the Black Plague, The Spanish Flu, and Smallpox.
- In a more lighthearted version, when playing the "Ultimate Board Games" scenario, you'll get messages that your game has sold more than Cards Against Humanity, Exploding Kittens, Cluedo, Scrabble and Monopoly.
- On a similar note, the Fake News scenario records your progress through comparing it to real fake news, such as flat-earth, anti-vaxx, and more.
Hoist by Their Own Petard:
- One of the ways to lose is by making your disease too lethal too fast. People will start dying faster than they are infected, and eventually the last carriers will die before having a chance to spread it around to the few people still alive, eradicating the disease. You can also make it too brutal too fast and drive people to shut down entrances and hammer away at the cure before you can react.
- It's entirely possible for vampires to kill every last living human without ever employing the Shadow Plague. Doing so results in a victory, but the screen notes the vampires have doomed themselves to starvation and death now that humanity is extinct.
Hollywood Evolution: Every copy of your disease has the same traits. You can spread your harmless little parasites throughout most of the world, and then give every single one the ability to cause heart attacks simultaneously.
Hope Spot: For the humans, anyway. It's possible for them to complete the cure and start distributing it, only for the cure to be rendered useless through Genetic Reshuffle or similar obtained afterward.
Horror Hunger: Cannibalism before zombie symptoms in Necroa mode. Mad Cow Disease can also cause this if you go down the mental path.
Humanity's Wake: A dead planet most of the time, mind controlled humans in Neurax Mode, Zombies in Necroa Mode, Neanderthals in the Frozen Virus, a world controlled by apes in the Simian Flu, and humanity enslaved by vampires in the Shadow Plague.
I Did What I Had to Do: Do things right and soon every country will do whatever it takes to impede your progress, as the news feeds go from bad to worse:
- From: closing borders to institutionalizing the sick to executing the sick! Stops land transmissions.
- From: killing rats/pigeons and banning livestock to culling all rodents/birds/livestock. Stops animal transmissions.
- From: doctors disregarding safety measures to legalizing human experimentation. Cure meter rises faster.
- Upgrade to get the Insanity symptom, and watch as the world spirals into madness. Cue Random Events such as nuclear plant meltdowns, countries nuking each other, and the World Cup getting cancelled.
- Governments can and will bomb infected areas.
Increasingly Lethal Enemy:
- Z-Com in the Necroa Virus mode. Every fortification of theirs will grow stronger over time. They start off with one fortification, and if not dealt with in time, will send planes over to other countries to establish more fortifications that will send more planes if not dealt with. As such, it's essential to get your zombies to take down their fortifications quickly.
- Templars in the Shadow Plague mode. Like Z-Com, the Templars will become stronger in their country over time, which makes it important to remove them quickly. While normally they don't establish more bases^note, they instead grow stronger each time another Templar base is destroyed.
- The Bio-Weapon in The Cure mode. Every new country it infects increases its already high infectivity and lethality further, which causes it to infect more countries even more rapidly. Needless to say, this can quickly become a Cycle of Hurting that demands exceptional measures to break.
Instant-Win Condition: Downplayed. The Neurax Worm, Bio-Weapon, and the Shadow Plague all have symptoms that pretty much guarantee victory... if you use them right:
- The Neurax Worm has "Transcendence", which makes the infected view the virus as a god and refuse to continue searching for a cure. Use it when everyone is already infected, and you win automatically.
  - Santa's Little Helper and Cuddle Bug do the same thing, minus having to evolve that symptom; just infect everyone and you've won.
- The Bio-Weapon has "Annihilate Gene", which maxes out your Lethality instantly, and makes the other two stats skyrocket. Use it when everyone is already infected and watch people drop faster than flies, but use it too early, and your disease will run a heavy risk of burning itself out.
- "Shadow Slaves" is the Shadow Plague's answer to "Transcendence", inciting a state of permanent psychosis in the infected, causing them to become slaves to the vampire.
- The Frozen Virus has "Neanderthal Regression", which causes the infected to revert back to Neanderthals. Like "Transcendence", evolving it when everyone is infected is an instant win.
- Zombies vs. Earth is this trope if your zombies manages to kill all Z-Com bases, with your zombies converting any uninfected countries into zombies. Justified since without any military to organize the defense, every country is screwed against the zombies.
- The Xenolith only needs to turn the entire Earth into a crystalline structure. It doesn't matter if the humans are almost about to fully turn your crystals inert if every country is fully converted. The win description even state that humanity will die shortly after. All of its secret Multiple Endings also immediately end the game once achieved even if the planet is not fully terraformed (though getting close helps with some of them):
  - If Gravimetric Tether is fully upgraded while starting with Star Shards, hitting the same country five times in a row will instantly trigger an Earth-Shattering Kaboom.
  - If Crystal Alignment is fully upgraded while starting with Synaptic Pulse, reaching 85% xenoforming and releasing an Alignment pulse in every continent at once while all countries are infected will turn Earth into a Genius Loci.
  - If a Shatter activation kills more than half the world's population while starting with Void Signal, the Xenolith sends a signal to an unknown entity (implied to be an Expy of the Scrin race), sealing the fate of the remaining humans.
- Within Outbreak mode, some modifiers allows you to instantly win the game provided their conditions are set:
  - Finger Snap will kill every infected instantly if you devolve a trait. Obviously you instantly lose if you forget to infect everyone when you devolve a trait.
  - Mind Over Matter is a lot easier to achieve. Just infect everyone and you instantly win as well.
Ironic Nursery Tune: For their PAX 2012 trailer, what could be more appropriate than "Ring Around The Rosie"? A patch also adds this in as a background noise being sung by a young girl that is played for the late game stages.
It Can Think: You play a (presumably) sentient and malevolent pathogen out to eradicate the entire human race. This is definitely the case with the Shadow Plague.
Jack of All Stats: The first plague, Bacteria is the most mundane and consistent plague to work with. It has no special abilities or gimmicks to help it spread, but it also has no drawbacks that can come back to bite it. Its unique ability Bacterial Resilience gives it a boost to infectivity in all environments. It's also one of the plagues that refunds DNA to devolve symptoms instead of costing DNA to devolve them.
Kill All Humans: The objective of the game. Alternatively, they could be mind controlled for the Neurax Worm, Zombified for the Necroa Virus, devolve them for the Frozen Virus, enslave them for the Shadow Plague, make everyone think the truth is to not be believed in Fake News, or get all to buy your board game in Ultimate Board Games.
Killer Robot: The Nano-Virus is a nanobot with the ability to replicate itself that seeks to kill all humans.
Kill One, Others Get Stronger: When playing as the Shadow Plague, each destroyed Templar base will send survivors to the others to make them stronger.

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Lampshade Hanging: Some of the random events point out the oddities of the world map, from Korea being a single region (they unified, but there's still a Demilitarized Zone that the soldiers threaten to go on strike over), to Alaska being a part of Canada (which got it in the "famous Hay-Herbert treaty"), to Denmark being a part of Germany (the German government has trouble with the "Danish Mafia becoming too powerful.").
Late to the Realization: Unintentionally on occasion. If your plague starts wiping out people extremely quickly, there will be many infection and death news stories before the WHO finally gets around to issuing a health advisory. It can get particularly absurd if the health bulletin is put out after countries have already collapsed or resorting to desperate measures.
Level Editor: The Scenario Creator in Evolved allows players to create custom scenarios, ranging from entirely new plagues to altered Earths.
Lighter and Softer: The Santa's Little Helper scenario. The world becomes so gloomy and unhappy that even the Neurax Worm gets angry and infects the world to bring joy everywhere.
- The Neurax Worm in general could be considered this, considering that you are given the option to enslave humanity rather than wipe it out, and the comical news even remains for far longer than any other plague.
- The "Ultimate Board Games" scenario takes this trope even further, having you sell the best board game you can design, not craft up a disease and kill everyone with it like usual.
- The "Fake News" scenario also doesn't involve killing people with disease, but instead influencing them with fake news (though you may kill them indirectly if you choose to).
Luck-Based Mission:
- Mutations. These are random, sometimes you'll get one that helps Infectivity which is good in the early/mid game but useless once you've infected everyone, sometimes you'll get a highly lethal symptom which is great when everyone is infected but bad if you haven't spread around much as it can cause you to kill faster than you infect or to get detected earlier than planned.
- Good luck getting DNA for the Necroa Virus when you spent it all on Transmission!
- The Fungus' Spore Burst and Spore Eruption both release plague spores into random countries (one in the former, five in the latter). Hope you managed to hit a strategic or a hard-to-reach country!
Magic Versus Science: The Shadow Plague scenario. Supernatural vampires with the ability to teleport and spread a supernatural disease vs. technologically advanced humanity with Templar forces, Attack Drones, and methods to cure said disease. Your goal is to help the magic side win.
Magikarp Power: One of the symptom paths for the Simian Flu increases intelligence in humans, thereby increasing the cure research speed. It has three variations, causing the cure research to speed up drastically for each one. If you evolve them all? You gain access to the "Total Brain Death" symptom, which is one of the most lethal symptoms in the entire game, being beaten out only by the Bio Weapon's Annihilate Gene.
Manchild: The "Immaturity" symptom that appears in certain custom plagues increases Infectivity due to lack of hygiene. And possibly lots of acne.
Marathon Level:
- The Necroa Virus can become this if you opt to forgo the zombies.
- The Fungus plague type, with its slow transmission, can drag on at times.
Meaningful Background Event: Yellow updates after evolving Cytopathic Reanimation in Necroa Mode frequently refer to increasing signs of zombie activity, such as a person's "miracle" survival in a car crash, or a mother claiming that her dead child attacked her.
A Million Is a Statistic: Or, rather, eight billion is a statistic. Averted from the humans' perspective, as they will panic and resort to desperate measures once large numbers of people start dying.
Minmaxer's Delight:
- Saudi Arabia is one of the best possible places to start in in almost all speedrun scenarios. It is the only non-rich country with an airport that can send to/receive from all other countries with an airport, and has a seaport (that sends ships to Madagascar, no less), allowing you to spread very quickly once you've established an infection foothold there. Usually, your first priority when starting there is to take air or water transmission to spread even more quickly.
- China and India are also two great places to start in thanks to their high population density, meaning that you get more infectees easily. This results in a lot of early-game DNA with which you can quickly evolve your disease. You also get two perks. The former borders Russia, one great country to get into Greenland, the latter nets you a Heat Resistance, which is slightly more expensive than Cold Resistance, meaning you can save on a bit of DNA.
- On the symptoms side, Necrosis is a popular choice for speedrunners. It allows the deceased to act as a transmission vector, allowing you to start killing early on without worrying about your disease burning itself out by killing too quickly. It's common in Mega-Brutal strategies for the same reason, but with the added wrinkle that, if evolved too early, countries will panic and shut down everything sooner than viable.
Monster in the Ice:
- The Frozen Virus has been frozen for more than 30 millennia in the Siberian permafrost before thawing and infecting the first humans. It always begins the game in Russia with maximum Cold Resistance evolved. The Cure mode version is mostly same, except it can start in any cold country, not just Russia.
- In the Zombies Vs. Earth Official Scenario, Greenland is the preselected starting location for the zombies to start out from. The backstory describes the zombies coming out from a melting glacier and slaughtering Greenland's populace overnight.
Multiple-Choice Past:
- Interestingly, the Necroa Virus has four possible backstories. To get each of them, you have to start in a specific country and evolve Saliva 1 and one other trait within 60 in-game days:
  - By starting in the USA and evolving Drug Resistance 1, a company named Darkwater is mentioned in red in the news. Once you get to the middle point, Darkwater admits to creating the virus as a bioweapon and does a Heel–Face Turn of sorts to combat it.
  - By starting in Egypt and evolving Heat Resistance 1, reports of an expedition into an ancient tomb will appear in the news. After some progress, the disease is said to have been dormant and originated from such tombs, with bite marks on mummies and ancient readings of plagues.
  - By starting in Ukraine and evolving Zoonotic Shift, the disease is eventually said to have come from infected animals dwelling in the remains of Chernobyl.
  - By starting in the UK and evolving Segmented Genome, the news will say that the disease was the result of an AIDS cure Gone Horribly Wrong.
- The Shadow Plague also has three possible origin stories, all requiring you to remain unnoticed for a long time to unlock. They involve either Dracula (if your starting country was Central Europe), the world's deepest cave network (Turkey), or damage to Stonehenge uncovering a sacrificial pit (UK).
Mutual Kill: If the vampire succeeds in wiping out humanity conventionally and has no Shadow Slaves, the popup just before victory notes that the vampire has essentially doomed themself to starvation and subsequent death, as there's no-one left for them to feed off. A similar popup occurs should the Necroa Virus win, explaining that the zombies will simply just decay away over time and leave the world barren.
Mythology Gag: Simian Flu, the virus from Dawn of the Planet of the Apes, has several of these:
- If you choose to start in the USA, the Gen-Sys lab will be located in San Francisco, where the events of Rise of the Planet of the Apes took place.
- When apes break out and escape the first Gen-Sys lab, the news may mention the CEO's president having been killed during the breakout, which is exactly what happened to Steven Jacobs, the Big Bad of Rise.
- The Total Brain Death symptom describes the infected dying because of their own immune reaction to the virus. In Rise, this is what ultimately causes Charles Rodman's death after a seemingly swift recovery from Alzheimer's disease.
- One achievement, Film Fanatic, requires you to recreate the events of the original film by starting in the USA and letting a small percentage of human population recover while killing off all the rest and having intelligent apes spread all over the planet.
My Country, Right or Wrong: A news ticker update: "Police set up politician.".
My Skull Runneth Over: The Simian Flu can do this. Three symptoms grant increasing levels of Super-Intelligence to humans, making work on the cure much faster. The fourth, after buying all three? Dramatically increases the Flu's Lethality. It's potentially that plague's best "kill switch".
News Travels Fast: The updates happen faster than the news bar can display them.
Next Sunday A.D.: The game begins on the date you launch it, progressing at around one day per second.
Nice Job Fixing It, Villain!: Evolving towards "Total Brain Death" of the Simian Flu increases human intelligence beforehand, increasing cure speed, therefore, if you do this but don't reach Total Brain Death before the cure completes, then you handed victory to the humans without meaning to.
No Campaign for the Wicked: Inverted for humanity until the release of The Cure game mode, though Downplayed in that the list of plagues you can fight in that mode stops at "Bio-Weapon", not counting the Frozen Virus.
No Celebrities Were Harmed: Many real life events and people are alluded to in Plague Inc., but with parodied names to avoid legal issues and/or controversy.
- If the American president has to stand down due to ill-health and if The Plague has the Insanity symptom, Spalin will be elected to take the office. Spalin will then threaten either Russia or China with nuclear war depending on the symptoms that the disease has, claiming that it is a bio-weapon of their creation. If the military generals are paralyzed from the disease, Spalin will carry through on the threat and kill everyone in that country. Spalin may also be based on Joseph Stalin with his extreme measures against his political opponents. In fact, some localizations (such as Russian) refer to Spalin as "he".
- In the Nipah Virus scenario, you can get an achievement for killing Kim Kardashian’s dog.
Non-Standard Game Over: As opposed to getting cured or killing every infected person and leaving some untouched by the plague, with the Simian Flu you can, by making all Apes intelligent (every single one on the planet, that is), letting no more than 60,000 of them die, killing no humans and getting no increases to Severity, and allowing the disease to be cured, get the Achievement "The Future Is Bright", humans and Apes having learned to coexist in peace. This is counted as a loss and you'll still get the standard Defeat screen, however.
Not Using the "Z" Word: Forced to confront the issue, governments say the virus can cause "pathological aggression in corpses" but claim the situation is under control^note.
Nuke 'Em: If Spalin is elected to office via evolving Insanity, and Paralysis is evolved in time, either Russia or China will be nuked, depending on if you got Cold Resistance or Bird Transmission. This instantly kills the country's entire population.
Obvious Rule Patch:
- One could trivialize a Fungus run on Normal by having Patho-stasis to keep Spore Burst at 1 DNA, evolving it, then devolving it which always refunded 2 DNA before repeating the process. This allowed the player to stack up DNA points while simultaneously infecting several countries even before the game starts proper. This was quickly noticed and patched out by making Spore Burst be unable to be devolved.
- The Simian Flu is severely Nerfed in the "Where Is Everyone?" scenario. Before the patch, overwhelming the few remaining humans was trivially easy since that scenario didn’t account for the infected apes.
- In Update 1.23 of Evolved, the "Cure Mania"^note, "Herd Immunity"^note, and the "Anti-Vax"^note scenarios were released alongside the update. Alongside the "Science Denial"^note, "Teleportation"^note, and "Shut Down Everything"^note scenarios, none of them allow the usage of the Special Plagues since for the Special Plagues, invoked they all have at least one way to break the scenario into pieces easily.
One-Hit Kill: The final ability of the Bio-weapon, Annihilation Gene, makes it so lethal that Total Organ Failure looks like a mild cold ^note. If the whole world is already infected, evolving it wins the game in a few seconds.
Ominous Latin Chanting/Ominous Pipe Organ: Both are featured on the Shadow Plague theme.
Omnicidal Maniac: You play as this, with the plague's ultimate goal being to exterminate all human life on Earth. Potentially subverted in the case of the Neurax Worm or Shadow Plague, which both offer the option to enslave humanity via brainwashing rather than simply slaughtering everyone.
Organ Theft: Well, self Organ Theft, as a result from evolving the Insanity symptom combined with Hyper Sensitivity in the Artificial Organs scenario.
Our Vampires Are Different: The Shadow Plague: a sentient pathogen with traits of bat-borne diseases that was buried underground with an infected human for many years. It can cause victims to turn psychotic and worship the awakened vampire, as well as mutate any new infectees into new vampires to assist in turning the globe into slaves.
Our Zombies Are Different: The Necroa Virus features a wide range of zombie tropes and Shout Outs. These can run, swim, spit acid, and revive themselves as many times as your DNA count allows.
Parasite Zombie: You can invoke this with the aggression symptom, which causes Neurax Worm infectees to display aggression towards uninfected people.
Patient Zero: Sometimes, a side event will involve the CDC looking for the Patient Zero to whatever your plague is.
Pacifist Run: This is possible via the Neurax Worm. In this scenario, the goal is to assimilate everyone in the worm's mind control, not killing everyone. If you're going for a Non-Standard Game Over, there's also an option to do this with the Simian Flu, evolving apes without killing humans.
Perspective Flip:
- In-Universe, the CDC can release a video game about curing a global pandemic. Said game, called Solve The Outbreak, is actually a real game made by the CDC and can be played here.
- The Cure game mode consists in coordinating a global response to fight against a pandemic.
The Plague: You play as a disease attempting to wipe out humanity.
Plot-Triggering Death: When the first disease victim dies, shit gets real. Assuming none of these have happened yet, this is usually the point where cure research either starts or picks up speed; seaports, airports, and land borders start shutting down; and extreme measures to find a cure or slow the infection start being taken.
Poke the Poodle: It's entirely possible to make diseases with non-lethal symptoms of varying inconvenience, like Sweating, Vomiting, Insomnia, and Skin Lesions.
Potty Failure: Evolving both Diarrhoea and Insanity in the same disease gets a unique symptom combo, faster research for a cure, and the "Brown Streets" achievement. Sneezing and Diarrhoea can earn the "Oops" combo.
Power Incontinence: The Bio-Weapon is too powerful for its own good—it automatically kills people it infects even if they have no symptoms, and it gets more lethal over time. On the plus side, this means people can start dropping dead for no apparent reason and the authorities won't identify the plague and start researching a cure. On the downside, this means that it has a strong tendency to burn itself out by killing its hosts too quickly unless you spread everywhere, fast.
Present Day Present Time: The game links to your device's clock so your plague starts on the day you start playing on. However, certain custom scenarios subverts this.
Press Start to Game Over:
- In Outbreak mode, each outbreak can have modifiers that change the difficulty of the scenario, including modifiers that affect orange DNA bubbles. Some modifiers cause ignoring an orange bubble to either cure the entire country's population or kill them. Other modifiers cause popping an orange bubble to either cure the entire country's population or kill them. Since orange bubbles can spawn early game before the pathogen has spread to any other country, it is possible for a player to either accidentally pop or ignore the first bubble and immediately eliminate the entire infected population, ending the attempt almost as soon as it begins^note.
- In Outbreak Mode, if the modifier "Whoops" is active (Evolving a trait destroys a random country's population), it's possible for the modifier to target your only infected country before you've spread elsewhere. Since destroying your last infected country immediately ends the game, you can lose just a few trait evolutions into the run.
Private Military Contractors: The Shadow Plague campaign has Templar Industries (whose duties include vampire hunting), while Necroa Virus has DarkWater (a composite of the Umbrella Corporation and the real-world Blackwater).
Properly Paranoid:
- Everyone in the Shut Down Everything scenario, with random countries going into lockdown even if you have low severity.
- Interestingly, the CDC has taken this game as a simulation warning should an outbreak actually happen in Real Life. See Shown Their Work.
- The best example is the "Peer Pressure" achievement. You can easily get it by having only one unnoticeable symptom like "sneezing". The doctors will not notice, the government will ignore it, but the people will riot over it. Forcing them to investigate, months later, the government will confirm the plague, alerting other countries while the cure starts, although at minimal priority.
- The doctors or government may still discover your disease anyway if it's a Necroa Virus with a low Severity, due to it causing the infected to express unusual anti-social behavior.
- The Shadow Plague if Shadow Blessing has been purchased, as the pathogen causes severe bruising to occur in infectees.
- All the countries had a description who makes a very short resume of his story.
Psychic-Assisted Suicide: Well, more like Possession Assisted Suicide, but the Neurax Worm can do this.
Puppeteer Parasite: The Neurax Worm. It even has a special interface viewer representing the Severity of its cerebral infection, depicted by nerve tendrils leading from its mandibles to a human brain.
Pyrrhic Victory: Possible for the humans if they manage to create a cure for your disease after killing most of humanity: even if the remaining humans don't have to live under the threat of your disease, it will take a very long time for civilization to rebuild, it it can rebuild at all — before taking into account the fact that humanity's population may be below the point of genetic viability.

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Race Against the Clock:
- This comes into play from both sides once the cure is started; will humanity win the race and complete the cure before you shut them down, or will you win the race and kill them all?
- The Nano-Virus is this entirely, as cure research begins the moment you do, complete with special abilities for spreading even quicker and for delaying cure progress even more effectively.
- Getting 5 biohazards (3 in scenarios) typically requires you to beat the game within one in-game year (on top of having less than 55% cure progress, a race in and of itself).
- The special backstories for the Necroa Virus require you to evolve the needed traits within 60 in-game days.
- "Ultimate Board Games" only lasts two in-game years regardless of what you do. That's how long you have to develop, produce, and distribute your board game and make it a smash hit.
- Cure Mode pulls an interesting twist: you still have to complete the cure before the plague kills everyone, but you also have to deal with non-compliance and your ever so dwindling authority bar, the latter of which will result in a game over when it reaches zero.
Raising the Steaks: Necroa's Zoonotic Shift tree allows the virus to zombify animals, perhaps even before zombifying the humans!
Random Event: Some of the achievements require the player to trigger certain events, either by accident or by choice. Some are easy to trigger, some require luck, even if you follow a guide and do things right.
Removing the Head or Destroying the Brain: Necroa cannot reanimate headless corpses until "Cranial Metastasis" is evolved. The mutation "Cranial Elephantitis" increases the skull's thickness, making it harder to re-kill zombies.
Ridiculously Cute Critter: The Neurax Worm's icon◊ for the Christmas scenario.
Ripped from the Headlines: Some events in the news ticker are updated every few months. During the later quarter of 2013, one news ticker mentioned the US Government Shutdown. The 2012 Olympics in Britain were updated to the Rio Olympics in 2016, then to the Tokyo Olympics in 2021, and then to the LA Olympics in 2025, as was the event that causes concern over whether or not an epidemic would be caused. After the referendum in 2016, news ticker messages started to mention Brexit.
"Risk"-Style Map: A completely flat map of the world is your playing field.
Save Scumming: The game decides when a mutation will occur before it happens, but the mutation itself is randomly chosen the second it happens. Players with save games can reload beforehand if the mutation is bad and try to get a better one. Particularly useful for Parasite, which lacks a lot of DNA points. In the Steam update, the game pauses entirely to alert the player that a mutation has occurred, players can then devolve the mutation as it happens thus nullifying the need to save scum as often.
Saving Christmas: In a scenario released for the 2014 Holiday season, "Fun" has been banned globally, and it's up to the Neurax Worm (XMA-3) to bring happiness back just in time for Christmas. Most of the News ticker updates consist of Christmas-themed references, such as a partridge getting shot off a pear tree.
Scandalgate: Parodied. The default name for your plague in the "Fake News" scenario is "Fake-gate".
Scenery-Based Societal Barometer: In Evolved, each country has a picture of a city within it in its information bar/page. This scene gradually changes as your disease ravages the country more and more, showing the increasing breakdown of society in the face of panic and civil unrest.
Scenery Gorn: Evolved shows pictures of famous national venues when you see a country's information bar/page. These pictures reflect the state of social disorder — everything looks fine at first, then you start seeing field hospitals or riot control squads, and finally, you see everything destroyed, on fire and with big banners with desperate pleas for help in the local language.
Shoo Out the Clowns: Once your plague starts being treated as a serious threat, the news ticker stops broadcasting silly headlines and shifts into Apocalyptic Log mode.
Shout-Out: There are numerous shout-outs to other franchises in the form of humorous news-ticker updates; in fact, there are so many that they've been moved to their own page!
Shown Their Work:
- Enough to get recognized by the CDC themselves. Real Life CDC updates are shown in blue in the news bar.
- One of the alerts says "Latest research shows that cold countries are getting significantly colder due to global warming." Despite the term of "global warming", climatologists have found that winters have actually been getting colder over the last decades because of it. ^note
- All of the real diseases featured in the official scenarios, like the Black Death and Smallpox, have "About" tabs that link to webpages about the diseases and their real life traits.
- The Cure, meanwhile, is based upon a well-informed and close observation of how the world reacted to COVID-19 in 2020.
Sleazy Politician: A news ticker update: "Politician makes polygraph machine explode.".
Sliding Scale of Undead Regeneration: Upgrading a certain ability (which revives the dead population, becoming zombies) allows for Type III if fully upgraded. Otherwise a Type I, with the victory screen mentioning that all zombies will soon perish, leaving the earth empty. You can even complete the scenario without ever reanimating the dead, which earns an extra achievement.
Spreading Disaster Map Graphic: The parts of the map that are infected by a deadly plague become more and more covered in tiny red/orange/yellow/black/purple dots until the entire country is covered in the plague's respective colour. This is the infection phase. When these countries face fatalities, the more people that die, the more the countries turn darker. Furthermore, ships and planes that carry the infection leave a red or orange trail.
Stealth-Based Mission:
- Humanity won't react at all until your disease is actually spotted, meaning that creating an asymptomatic disease and infecting most of the world is a viable strategy for most plagues. Even when it's discovered, a low severity will cause them to react more slowly. Subverted in Mega Brutal, where humanity will immediately go full-throttle on the cure regardless of severity once you're uncovered (and you will be within a few months.)
- Defied by the Nano-Virus - humanity knows about the disease from the start and is working to shut the rogue nanomachines down from minute one, preventing any kind of stealth run.
"Stop Having Fun" Guys: Both an in-universe example and taken literally. They've apparently taken over the world in the Christmas scenario.
Surprisingly Sudden Death: From the player's perspective, anyway. Evolve a lethal symptom and count up to 10. Someone will die by then if it's minorly lethal.

T-Z

Take That!:
- The Science Denial scenario is essentially a jab towards Flat Earthers, climate change deniers, anti-vaxxers, and modern trends in science denial and anti-intellectualism. Of all these trends, the whole scenario is a haymaker aimed directly towards the anti-vaccine community. You essentially exploit the folly of the anti-vaxxers, as research on the cure will be continuously stifled by science deniers at almost every major step and it's a major factor in the player's victory no matter how it plays out.
- The Fake News scenario very similar to the above, but up to eleven. As you are the one who writes and distributes the bullcrap that the people can consume.
- Within the Fake News scenario, you have to select who starts the fake news and who it's blamed on. In both of these, feces is used as the icon for "Racists". On a similar note, "Politicians" have the Necroa Virus zombie icon, and both "Communists" and "Fascists" have the Shadow Plague cultist icon.
- One news headline added with the Mutation 1.23 update that accompanied the Aliens & Anti-Vaxxers DLC, "Roblox CEO proposes 'Age of Consent' reform", mocks the time when David Basuzcki suggested adding online dating-oriented features to Roblox, a video game platform for all ages which has an infamous reputation for exposing minors to inappropriate content since the early 2020s, due to active communities of its playerbase engaging in online dating and lewd roleplay.
Technically Living Zombie: The Necroa Virus can cause victims to stumble around and feel compelled to eat others (or themselves!) before it actually starts reanimating the dead. There's even an achievement called "Not Another Zombie Game," obtained by winning the Necroa Virus mode without evolving any reanimation effects.
There Is No Kill Like Overkill:
- It's possible to have all the lethal symptoms active at once.
- If you get the US president ill and do several things afterwards^note, the US can nuke Russia and/or China.
- The Bio-Weapon's "Unlock Annihilate Gene" ability maxes out the plague's lethality (+100% lethality, four times as deadly as Total Organ Failure) while also significantly boosting infectivity and severity. The result is usually every infectee dying in a minute or so at most.
- One of the possible outcomes for the Xenolith ends with shattering the entire planet due to constant meteor strikes.
Toilet Humour: Those combos that require diarrhea as one of their components.
- One of the combos in the Simian Flu mode, Rude Awakening, qualifies.
- The Shadow Plague has the combo Silent But Deadly, which causes a bad smell to come from nowhere.
Temporary Online Content: In 2026, during the entire February, the Santa's Little Helper scenario was replaced with Cuddle Bug, another Neurax Worm-themed scenario with a Crapsack World, where you instead infect people with love and passion; the symptoms are slightly different, and so are the government's actions.
The Topic of Cancer:
- The "Tumors" symptom causes the infection to start creating cancerous growths in its victims.
- The Necroa Virus is initially placed on the watchlist because its regenerative abilities could cause it to overcharge cell division, leading to this. Of course, it soon proves itself worse than that.
Too Dumb to Live:
- Most humans on Casual or in The Cure mode, Mega Brutal. The Plague is threatening the world? Let's hug the infected and never wash our hands.
- The Anti-Science scenario has people sabotage the cure in favor of healing crystals (despite people dropping dead rapidly), and ending quarantine should science fail. Even if the cure is complete the first time, the governments will immediately destroy it, resetting the progress bar almost to the start.
- Sometimes in the Necroa Virus scenario, Z-Com can form in countries full or nearly full of zombies even if there's a much better option available.
Took a Level in Badass: Greenland, compared to Pandemic. In Pandemic, Greenland was infamous for being Too Dumb to Live once infected. Here it's basically to Plague Inc. what Madagascar was to Pandemic.
The Computer Is a Cheating Bastard: Sometimes, after a while of you being detected and there have been not too much efforts put into the cure, the game might trigger an Awareness Day, which will cause each country to install one research lab, allowing the cure to went up fast early on when you don't have a good start yet. This is more likely to occurs if your disease is high in Severity and Lethality. The Smallpox scenario had it the worst, since not only you will be detected very early on due to the disease's high Severity, but the cure is a lot faster than usual (mimicking the fact that humanity once eradicate Smallpox) so getting one may already means game over for you there.
- The WHO - Threat level increase is another event similar to Awareness Day. While the effect is not as strong, this is made up by it can appears with Awareness Day as well, and their effects stack.
- Also, both events will lead to the WHO Watchlist early on, which not only boost the cure but also making countries more likely to close their connection, so even if the super fast cure isn't a problem with you, the high risk of being locked out of an island would be.
- In any Outbreak level with a modifier that reduce your efficiency on Hot/Cold countries, if you got the Awareness Day, then you already lose, as barely being able to spread meaning every second count, so you cannot afford for the Cure to go up at lightning speed and giving you even less time.
Travel Transformation: In the vampire plague expansion, your vampire will move about the globe by transforming into a bat while traveling to its destination.
Trial-and-Error Gameplay: Brutal mode for any disease type sans cheats. Governments are very quick to act, and only with massive foresight can you avoid the consequences of human reaction. Mega-Brutal is even more unforgiving to the player.
Unintentionally Unwinnable: Some custom scenarios that remove the Air and Water transmissions don't take into account the "Sterilization" random events, which require those transmissions to bypass. Losing the ability to spread via airplanes doesn't sting as much since every country has either a land border or a seaport, but losing the ability to spread via ships can render the game unwinnable since not every country that lacks a land border has an airport, rendering such countries inaccessible unless you're playing with the Neurax Worm (Trojan Planes) or Fungus (Spore abilities) or the disease has an analogue to one of those abilities, but most custom scenarios choose the disease type for you and the latter is uncommon.
Updated Re-release: Plague Inc: Evolved, released for Steam, includes multiplayer modes to infect the Earth together or fight each other over it, as well as custom scenarios^notelike a level editor before the mobile version added it later, updated graphics and a ton of other things. Available on Steam.
Unusually Uninteresting Sight: Averted. Having "vomiting" or any other extremely noticeable symptom will have everyone freak out and increases Severity.
Video Game Cruelty Potential:
- The number of horrible symptoms and sinister ways to spread the disease can cause one to feel like a supervillainous Omnicidal Maniac as you rain death down upon the world.
- Simian Flu allows you to kill off all of your intelligent apes by devolving Simian Neuro-Genesis while all apes in the world are infected. There is even an achievement for doing that.
Video Game Cruelty Punishment: On the other hand, making your disease horribly over the top and gruesome is a sure way to screw yourself over. Killing everyone too quickly with horrible combinations will quarantine the plague quickly, followed by curing unless all the infected die. That, or the infected will die faster than they can spread the disease, causing it to eventually die out with them.
Video Game Geography: The Earth is actually flat in Plague Inc, or at least the transportation methods act as such. For example, a plane travelling from the US West Coast to Australia will never cross the Pacific; it will cross the Atlantic and Indian Oceans.
Villain Protagonist: If you aren't trying to kill the entire world, you're either seeking to turn everyone into slaves to your Neurax Worm, Neanderthals or vampires, or make everyone believe fake news. The few times this trope is averted are if you're playing the Santa's Little Helper, Cuddle Bug, or Ultimate Board Games scenarios.
Violation of Common Sense: For those used to winning by remaining undetected until everyone's infected and then hitting the kill switch, the fact that most strategies for Mega-Brutal throw stealth out the window and start killing before that point (since time is of the essence, especially if you're going for a high score) can feel like this.
Walk, Don't Swim: A Necroa Virus upgrade tree allows zombie hordes to cross bodies of water (including entire oceans) faster. Subverted with an upgrade stating that they float down currents due to decomposition.
Whole-Plot Reference:
- To Resident Evil for the US version of the Necroa Virus: An unscrupulous company creates a mutagenic zombie virus with intention of using it as a biological weapon, only for it to get out of control and cause an outbreak. The company is then left desperately trying to cover its ass, complete with employing Cleanup Crews and anti-zombie weaponry.
- The UK version's backstory is similar to 28 Days Later: The Virus was created for a completely benign reason by a lab in Britain but it mutated that made it dangerous to humans and was released during a lab accident.
- Several aspects of the Nipah Virus scenario are adapted from the movie Contagion (2011), from the virus being spread via bats and pigs as a consequence of the bats losing their habitat, to someone claiming that they were cured via a homeopathic remedy. The description even describes the plague as "...a Contagion worthy of Hollywood".
Willfully Weak: The various special abilities of the Bio-Weapon all serve to decrease its own Lethality in some way or another (except for the final one). They're needed in order to offset the Bio-Weapon's overly high Lethality which can lead to it killing too many hosts too early before they can infect others as well as alerting the governments.
You Are Already Dead: In Outbreak mode, if you ever get the combination of Fatal Retraction^note and Lost in Translation^note, you do not have a modifier that punishes you for evolving and/or devolving a trait, you are not playing a pathogen that needs to spend DNA to devolve a trait (e.g. Virus), and you can equip the Translesion gene^noteCost to devolve don't increase, you could basically kill everyone very quickly by just evolving one trait, devolving it, then devolving the new trait. You can even do this before the game even starts if you are given enough starting DNA or you have ATP boost equipped^noteGet bonus DNA at the beginning.
You Have Researched Breathing: In Simian Flu, if you want your apes to travel across the seas, you MUST evolve a seafaring ability. Though it does not stop you from sending an ape troop into the water without seafaring, with predictable consequences.
Zombie Apocalypse: Causing one is your main goal in the Necroa Virus plague type.
Zombie Puke Attack: The Necroa Virus' symptoms "Acidic Reflux" and "Naja Mortis" makes the infected projectile vomit, which increases combat efficiency and disease spread.

Tropes in The Cure

Ascended Extra: The Frozen Virus makes its return from the original game, originally being a modified Virus in a custom campaign, but is now made its own unique selection choice.
Brutal Honesty: "Expectation Management", an unique ability to combat the Bio-Weapon that's basically you saying "Some of you may die, but that is a sacrifice I am willing to make" (and Bio-Weapon being what it is, a Pacifist Run isn't really possible, especially on anything higher than Normal). This has an immediate Authority penalty, but reduces the rate at which Authority is lost going forward.
Damned by Faint Praise: "The [name] Bio-Weapon only killed 6,900,000,000 people in 180 days. I've saved the world!"
Easter Egg: Playing the Cure mode with a virus named "COVID-19" will put you against the actual COVID-19, depicted as a virus whose traits are "coughing", "sneezing", "pneumonia", "fever", "systemic infection", "asymptomatic" and "well understood".
Find the Cure: This is, of course, your mission in the game mode.
My Rules Are Not Your Rules: The more gimmicky disease types you can fight against have attributes that make your gameplay in The Cure harder, but are absent when you're playing as those disease types in the base game.
- In the base game, the Prion is crippled by low infectivity. In Cure Mode, it's one of the most infectious plague types.
- In the base game, the cure progress for the Nano-Virus starts immediately. In Cure Mode, you have to analyze it first, giving it a month or two to run wild before you can do anything.
- In the base game, the Bio-Weapon has to be carefully micromanaged to keep from burning out. In Cure Mode, it gets around this by ramping up in infectivity and lethality the more countries it infects.
- In the base game, once the cure reached 100%, the game is over unless you evolve something to bring it down. In the Cure Mode, you have to analyze for most diseases, and went through a Research phase and a Manufacturing phase.
- Oddly enough, there's also an inverted example: In the base game, if someone is infected, they stay infected for the rest of the game, even if that's years, unless they die or the cure is completed.^noteSome diseases can lie dormant in your system for years, such as shingles. But the clock to death or recovery starts ticking once symptoms start showing, especially those that are actually an immune response like fever. In Cure Mode, there's a set lethality rate for each plague (though it can still get ridiculous, see the Bio-Weapon), and people that don't die of it can actually recover on their own (and some response options can increase this recovery rate).
  - Another inverted example is that in the base game, the Virus mutate pretty often (with this mutation rate can even be increased with transmissions and abilities), giving you a ton of free symptoms, while in the Cure Mode, its mutation is just as rare as any other diseases. Speaking of mutation, most symptoms you mutate give infectivity, severity and lethality for some, but in the Cure Mode, the mutation are much weaker, only increase either Infectivity or Lethality, and in some rare case, both of these traits will actually decrease instead.
No Campaign for the Wicked: While this DLC finally averts this for at least half of the plague types, it's restricted to plagues where the only win condition is to kill everyone, and so only goes from Bacteria to Bio-Weapon. No fighting Zombies or Vampires in this gamemode.^note
Perspective Flip: The whole mode takes the opposite view of the base game, trying to cure the disease that you would otherwise be spreading.
Take That!: The difficulty settings have descriptions that lampoon misconceptions and troubles during the handling of the COVID-19 Pandemic. "Casual" states that people will love wearing masks, "Normal" claims that politicians will at least be "vaguely competent," "Brutal" boasts that "sick people inject disinfectant" and that "leaders ignore science", and "Mega Brutal" will have everyone believe in fake news. For extra salt in the wound, the soundtrack is called "Flatten the Curve."
Take That, Audience!: The "Mega Brutal" difficulty setting claims that "Doctors will play Plague Inc. all day."
Well-Intentioned Extremist: Some of the options you have for fighting the cure are pretty unsavory, such as deliberately spreading misinformation and/or censoring dissidents. Taken a step further on the Nano-Virus (which allows you to hijack people's emotions to lessen panic) and Bio-Weapon (which allows you to simply start executing infected populations en masse). At the end of the day, however, you are still working to save humanity. Deconstructed however in that these methods can lower your Authority and increase Non-Compliance, potentially making things worse in the long run.

Remember that in real life, moving to Greenland or any other island nation will not make you immune to deadly pathogens, especially if that's the starting location.

Plague Inc.

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